Bilateral oophorectomy and the risk of hepatocellular carcinoma in women with hepatitis C: A population-based study

doi:10.1016/j.maturitas.2020.12.006

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/34485

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34485

Title:	Bilateral oophorectomy and the risk of hepatocellular carcinoma in women with hepatitis C: A population-based study
Authors:	Chen, Chao-Yu Wang, Ting-Yao Chen, Wei-Ming Chen, Kai-Hua Yang, Yao-Hsu Chen, Pau-Chung Chen, Vincent Chin-Hung
Contributors:	Chang Gung Mem Hosp, Dept Obstet & Gynecol Chang Gung Mem Hosp, Dept Internal Med, Div Hematol & Oncol Chang Gung Mem Hosp, Dept Internal Med, Div Gastroenterol & Hepatol Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chang Gung Univ, Coll Med, Sch Med Chang Gung Mem Hosp, Dept Phys Med & Rehabil Chang Gung Mem Hosp, Hlth Informat & Epidemiol Lab Chang Gung Mem Hosp, Dept Tradit Chinese Med Chang Gung Univ, Coll Med, Sch Tradit Chinese Med Natl Taiwan Univ, Coll Publ Hlth, Inst Environm & Occupat Hlth Sci Natl Taiwan Univ, Coll Publ Hlth, Dept Publ Hlth Natl Taiwan Univ Hosp, Dept Environm & Occupat Med Natl Taiwan Univ, Coll Med Natl Taiwan Univ Hosp, Off Occupat Safety & Hlth, Taipei, Taiwan;[Chen, Vincent Chin-Hung Chang Gung Mem Hosp, Dept Psychiat, Puzi City Chang Gung Univ
Keywords:	Hepatitis C virus Hepatocellular carcinoma Oophorectomy National Health Insurance Research Database
Date:	2021
Issue Date:	2023-11-11 11:56:49 (UTC+8)
Publisher:	ELSEVIER IRELAND LTD
Abstract:	Objective: Patients with chronic hepatitis C virus (HCV) infection are at high risk of developing hepatocellular carcinoma (HCC). Previous studies suggested that menopause may increase the risk of HCC. We investigated the association between bilateral oophorectomy (BO) and the risk of HCC in women with HCV infection. Study design: We used data from the National Health Insurance Research Database of Taiwan and conducted a matched cohort study. Main outcome measures: The main outcome was HCC. We used a competing risk model to adjust for potential confounding factors. Results: From 1997-2013, we identified 2176 patients with BO and 8704 controls. A total of 107 HCC cases (4.9 %, 107/2176) were identified in the BO group compared with 465 HCC cases (5.3 %, 465/8704) in the control group. The incidence rates were 506.3 and 538.9 cases per 100,000 person-years among the HCV-infected pa-tients with and without BO, respectively. The competing risk model showed that BO did not increase the risk of developing HCC. Furthermore, a sub-analysis of only women under 50 years of age similarly showed that BO did not increase the risk of developing HCC after adjusting for additional covariates. The log-rank test revealed that whether or not the patients had received HRT, patients with BO did not have an increased risk of developing HCC (non-BO vs BO with HRT, p = 0.10; non-BO vs BO without HRT, p = 0.09). The use of HRT after BO did not influence the risk of developing HCC. Conclusions: This study examined a large dataset with a long follow-up period to test the relationship between BO and the risk of HCC in HCV-infected women. Our findings suggest that BO did not increase the risk of HCC, regardless of HRT usage, in these women.
Relation:	MATURITAS, v.146, pp.11-17
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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