Antimalarial primaquine for skin infiltration analgesia in rats

doi:10.1093/jpp/rgaa021

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/34479

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Title:	Antimalarial primaquine for skin infiltration analgesia in rats
Authors:	Chang, Ying-Jen Liu, Kuo-Sheng Wang, Jhi-Joung Chen, Yu-Wen Hung, Ching-Hsia
Contributors:	Chi Mei Med Ctr, Dept Anesthesiol Chang Jung Christian Univ, Coll Hlth Sci Chia Nan Univ Pharm & Sci, Dept Pharm Chi Mei Med Ctr, Dept Med Res Southern Taiwan Univ Sci & Technol, Allied AI Biomed Ctr China Med Univ, Coll Hlth Care, Dept Phys Therapy Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci
Keywords:	primaquine lidocaine antimalarial drugs skin infiltration anaesthesia
Date:	2021
Issue Date:	2023-11-11 11:56:29 (UTC+8)
Publisher:	OXFORD UNIV PRESS
Abstract:	Objectives The purpose of this study was to estimate the ability of antimalarial medications to induce local infiltration analgesia. Methods Using a rat model of skin infiltration anaesthesia, the effects of antimalarial medications (primaquine, chloroquine, hydroxychloroquine and amodiaquine) were compared with the application of lidocaine. Key findings At a dose of 3 mu mol, primaquine and chloroquine displayed better potency (all P < 0.05) and greater duration (all P < 0.01) of cutaneous analgesia than lidocaine, whereas the other antimalarial medications showed a similar potency and duration of cutaneous analgesia when compared with lidocaine. When a dose of 3 mu mol antimalarial medication was used, primaquine was the most potent and had the longest duration of action among four antimalarial medications. The relative potency ranking (ED50, 50% effective dose) has been found to be primaquine [2.10 (1.87 - 2.37) mu mol] > lidocaine [6.27 (5.32 -7.39) mu mol] (P < 0.01). Infiltration analgesia of skin with primaquine had a greater duration of action than did lidocaine on the equipotent (ED25, ED50, ED75) basis (P < 0.01). Conclusions Primaquine and chloroquine have greater potency and longer lasting skin analgesia when compared with lidocaine, while the other antimalarials display a similar potency in comparison with lidocaine.
Relation:	J PHARM PHARMACOL, v.73, n.2, pp.206-211
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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