Novel signaling pathways regulate SARS-CoV and SARS-CoV-2 infectious disease

doi:10.1097/MD.0000000000024321

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標題:	Novel signaling pathways regulate SARS-CoV and SARS-CoV-2 infectious disease
作者:	Cheng, Li-Chin Kao, Tzu-Jen Phan, Nam Nhut Chiao, Chung-Chieh Yen, Meng-Chi Chen, Chien-Fu Hung, Jui-Hsiang Jiang, Jia-Zhen Sun, Zhengda Wang, Chih-Yang Hsu, Hui-Ping
貢獻者:	Chi Mei Med Ctr, Dept Surg, Div Colorectal Surg Taipei Med Univ, Coll Med Sci & Technol, PhD Program Neural Regenerat Med Natl Hlth Res Inst Taipei Med Univ, TMU Res Ctr Neurosci Nguyen Tat Thanh NTT Univ, NTT Inst Hitechnol I Shou Univ, Sch Chinese Med Postbaccalaureate Kaohsiung Med Univ Hosp, Dept Emergency Med Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med Chia Nan Univ Pharm & Sci, Dept Biotechnol Fudan Univ, Huashan Hosp North, Emergency Dept Kaiser Permanente, Northern Calif Reg Labs, Permanente Med Grp Taipei Med Univ, PhD Program Canc Mol Biol & Drug Discovery, Coll Med Sci & Technol Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Biol & Drug Discovery Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg, Tainan, Taiwan;[Hsu, Hui-Ping Vanderbilt Univ, Med Ctr, Dept Biostat
關鍵字:	bioinformatics coronavirus interleukin-17 severe acute respiratory syndrome coronavirus severe acute respiratory syndrome coronavirus-2 tumor necrosis factor
日期:	2021
上傳時間:	2023-11-11 11:55:32 (UTC+8)
出版者:	LIPPINCOTT WILLIAMS & WILKINS
摘要:	Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 induces severe infection, and it is responsible for a worldwide disease outbreak starting in late 2019. Currently, there are no effective medications against coronavirus. In the present study, we utilized a holistic bioinformatics approach to study gene signatures of SARS-CoV- and SARS-CoV-2-infected Calu-3 lung adenocarcinoma cells. Through the Gene Ontology platform, we determined that several cytokine genes were up-regulated after SARS-CoV-2 infection, including TNF, IL6, CSF2, IFNL1, IL-17C, CXCL10, and CXCL11. Differentially regulated pathways were detected by the Kyoto Encyclopedia of Genes and Genomes, gene ontology, and Hallmark platform, including chemokines, cytokines, cytokine receptors, cytokine metabolism, inflammation, immune responses, and cellular responses to the virus. A Venn diagram was utilized to illustrate common overlapping genes from SARS-CoV- and SARS-CoV-2-infected datasets. An Ingenuity pathway analysis discovered an enrichment of tumor necrosis factor- (TNF-) and interleukin (IL)-17-related signaling in a gene set enrichment analysis. Downstream networks were predicted by the Database for Annotation, Visualization, and Integrated Discovery platform also revealed that TNF and TNF receptor 2 signaling elicited leukocyte recruitment, activation, and survival of host cells after coronavirus infection. Our discovery provides essential evidence for transcript regulation and downstream signaling of SARS-CoV and SARS-CoV-2 infection.
關聯:	MEDICINE, v.100, n.7, e24321
顯示於類別:	[生物科技系(所)] 期刊論文

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