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https://ir.cnu.edu.tw/handle/310902800/34467
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| 標題: | Novel signaling pathways regulate SARS-CoV and SARS-CoV-2 infectious disease |
| 作者: | Cheng, Li-Chin
Kao, Tzu-Jen
Phan, Nam Nhut
Chiao, Chung-Chieh
Yen, Meng-Chi
Chen, Chien-Fu
Hung, Jui-Hsiang
Jiang, Jia-Zhen
Sun, Zhengda
Wang, Chih-Yang
Hsu, Hui-Ping |
| 貢獻者: | Chi Mei Med Ctr, Dept Surg, Div Colorectal Surg
Taipei Med Univ, Coll Med Sci & Technol, PhD Program Neural Regenerat Med
Natl Hlth Res Inst
Taipei Med Univ, TMU Res Ctr Neurosci
Nguyen Tat Thanh NTT Univ, NTT Inst Hitechnol
I Shou Univ, Sch Chinese Med Postbaccalaureate
Kaohsiung Med Univ Hosp, Dept Emergency Med
Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med
Chia Nan Univ Pharm & Sci, Dept Biotechnol
Fudan Univ, Huashan Hosp North, Emergency Dept
Kaiser Permanente, Northern Calif Reg Labs, Permanente Med Grp
Taipei Med Univ, PhD Program Canc Mol Biol & Drug Discovery, Coll Med Sci & Technol
Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Biol & Drug Discovery
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg, Tainan, Taiwan;[Hsu, Hui-Ping
Vanderbilt Univ, Med Ctr, Dept Biostat |
| 關鍵字: | bioinformatics
coronavirus
interleukin-17
severe acute respiratory syndrome coronavirus
severe acute respiratory syndrome coronavirus-2
tumor necrosis factor |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:55:32 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 induces severe infection, and it is responsible for a worldwide disease outbreak starting in late 2019. Currently, there are no effective medications against coronavirus. In the present study, we utilized a holistic bioinformatics approach to study gene signatures of SARS-CoV- and SARS-CoV-2-infected Calu-3 lung adenocarcinoma cells. Through the Gene Ontology platform, we determined that several cytokine genes were up-regulated after SARS-CoV-2 infection, including TNF, IL6, CSF2, IFNL1, IL-17C, CXCL10, and CXCL11. Differentially regulated pathways were detected by the Kyoto Encyclopedia of Genes and Genomes, gene ontology, and Hallmark platform, including chemokines, cytokines, cytokine receptors, cytokine metabolism, inflammation, immune responses, and cellular responses to the virus. A Venn diagram was utilized to illustrate common overlapping genes from SARS-CoV- and SARS-CoV-2-infected datasets. An Ingenuity pathway analysis discovered an enrichment of tumor necrosis factor- (TNF-) and interleukin (IL)-17-related signaling in a gene set enrichment analysis. Downstream networks were predicted by the Database for Annotation, Visualization, and Integrated Discovery platform also revealed that TNF and TNF receptor 2 signaling elicited leukocyte recruitment, activation, and survival of host cells after coronavirus infection. Our discovery provides essential evidence for transcript regulation and downstream signaling of SARS-CoV and SARS-CoV-2 infection. |
| 關聯: | MEDICINE, v.100, n.7, e24321 |
| 顯示於類別: | [生物科技系(所)] 期刊論文
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