Formation and characterization of hydrogenated soybean lecithin/TPGS nano-dispersions as a potential carrier for active herbal agents

doi:10.1016/j.colsurfa.2020.125796

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/34466

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標題:	Formation and characterization of hydrogenated soybean lecithin/TPGS nano-dispersions as a potential carrier for active herbal agents
作者:	Shen, Po-Tsun Chiu, Shih-Wei Chang, Jia-Yaw Chung, Tze-Wen Liang, Chia-Hua Deng, Ming-Jay Chou, Tzung-Han
貢獻者:	Natl Hlth Res Inst, Core Instrument Ctr, Prot Chem Core Lab Natl Yunlin Univ Sci & Technol, Dept Chem & Mat Engn Natl Taiwan Univ Sci & Technol, Dept Chem Engn Natl Yang Ming Univ, Dept Biomed Engn Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Providence Univ, Dept Appl Chem
關鍵字:	D-alpha-tocopheryl polyethylene glycol 1000 succinate Physicochemical properties Thermotropic phase behavior Free radical-scavenging capacity In vitro biocompatibility
日期:	2021
上傳時間:	2023-11-11 11:55:23 (UTC+8)
出版者:	ELSEVIER
摘要:	The goal of this study was to examine the effects of lipid composition on physicochemical characteristics of hydrogenated soybean lecithin (HL)/d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) dispersions using dynamic light scattering, transmission electron microscopy, differential scanning calorimetry, and fluorescence polarization spectroscopy. Our results showed that HL-rich nano-dispersions exhibited larger size, narrower size distribution, higher negative zeta potential, more obvious phase transition regions, and lower membrane fluidity than did the TPGS-rich ones. The membrane packing order, intermolecular attraction interaction, and molecular cooperativity in the phase transition region of the HL dispersions could be reduced by the incorporation of a large amount of TPGS. Furthermore, chemical stability, a drug release profile, and free radical-scavenging capacity of HL/TPGS nano-dispersions encapsulating black soybean seed coat extract (BE) were analyzed. HL/TPGS nano-dispersions improved the stability and radical-scavenging capacity of phytochemicals, such as BE. Nano-dispersions with the molar ratio of HL/TPGS = 9/1 exhibited good storage stability, a slow BE release rate, good free radical-scavenging capacity, and high in vitro biocompatibility; thus, they could be a high-potential vehicle for carrying active herbal agents.
關聯:	COLLOID SURFACE A, v.611, 125796
顯示於類別:	[化妝品應用與管理系(所)] 期刊論文

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