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https://ir.cnu.edu.tw/handle/310902800/34466
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| 標題: | Formation and characterization of hydrogenated soybean lecithin/TPGS nano-dispersions as a potential carrier for active herbal agents |
| 作者: | Shen, Po-Tsun
Chiu, Shih-Wei
Chang, Jia-Yaw
Chung, Tze-Wen
Liang, Chia-Hua
Deng, Ming-Jay
Chou, Tzung-Han |
| 貢獻者: | Natl Hlth Res Inst, Core Instrument Ctr, Prot Chem Core Lab
Natl Yunlin Univ Sci & Technol, Dept Chem & Mat Engn
Natl Taiwan Univ Sci & Technol, Dept Chem Engn
Natl Yang Ming Univ, Dept Biomed Engn
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Providence Univ, Dept Appl Chem |
| 關鍵字: | D-alpha-tocopheryl polyethylene glycol 1000 succinate
Physicochemical properties
Thermotropic phase behavior
Free radical-scavenging capacity
In vitro biocompatibility |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:55:23 (UTC+8) |
| 出版者: | ELSEVIER |
| 摘要: | The goal of this study was to examine the effects of lipid composition on physicochemical characteristics of hydrogenated soybean lecithin (HL)/d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) dispersions using dynamic light scattering, transmission electron microscopy, differential scanning calorimetry, and fluorescence polarization spectroscopy. Our results showed that HL-rich nano-dispersions exhibited larger size, narrower size distribution, higher negative zeta potential, more obvious phase transition regions, and lower membrane fluidity than did the TPGS-rich ones. The membrane packing order, intermolecular attraction interaction, and molecular cooperativity in the phase transition region of the HL dispersions could be reduced by the incorporation of a large amount of TPGS. Furthermore, chemical stability, a drug release profile, and free radical-scavenging capacity of HL/TPGS nano-dispersions encapsulating black soybean seed coat extract (BE) were analyzed. HL/TPGS nano-dispersions improved the stability and radical-scavenging capacity of phytochemicals, such as BE. Nano-dispersions with the molar ratio of HL/TPGS = 9/1 exhibited good storage stability, a slow BE release rate, good free radical-scavenging capacity, and high in vitro biocompatibility; thus, they could be a high-potential vehicle for carrying active herbal agents. |
| 關聯: | COLLOID SURFACE A, v.611, 125796 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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