Hepatitis B virus seroprevalence among HIV-infected patients receiving combination antiretroviral therapy three decades after universal neonatal hepatitis B immunization

doi:10.1016/j.jmii.2019.10.005

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標題:	Hepatitis B virus seroprevalence among HIV-infected patients receiving combination antiretroviral therapy three decades after universal neonatal hepatitis B immunization
作者:	Lin, Jia-Juen Lin, Kuan-Yin Tang, Hung-Jen Lin, Shih-Ping Lee, Yi-Chien Liu, Chun-Eng Huang, Yu-Shan Wang, Ning-Chi Li, Chia-Wen Ko, Wen-Chien Yang, Hao-Jan Lee, Yuan-Ti Hung, Chien-Ching
貢獻者:	Chung Shan Med Univ Hosp, Dept Internal Med Chung Shan Med Univ, Dept Publ Hlth Natl Taiwan Univ Hosp, Dept Med, Jin Shan Branch Chi Mei Med Ctr, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Taichung Vet Gen Hosp, Dept Internal Med Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Internal Med Fu Jen Catholic Univ, Coll Med, Sch Med Changhua Christian Hosp, Dept Internal Med Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch Natl Taiwan Univ Hosp, Dept Internal Med Natl Taiwan Univ, Coll Med Triserv Gen Hosp, Dept Internal Med Natl Def Med Ctr, Taipei, Taiwan;[Li, Chia-Wen;Ko, Wen-Chien Natl Cheng Kung Univ Hosp, Dept Internal Med Natl Cheng Kung Univ, Dept Med, Med Coll Chung Shan Med Univ, Sch Med Natl Taiwan Univ, Dept Trop Med & Parasitol, Coll Med
關鍵字:	Men who have sex with men Neonatal vaccination Sexually transmitted infection Vertical transmission Viral hepatitis
日期:	2021
上傳時間:	2023-11-11 11:53:19 (UTC+8)
出版者:	ELSEVIER TAIWAN
摘要:	Background/purpose: This multicenter study aimed to evaluate the seroprevalence of hepatitis B virus (HBV) and the use of combination antiretroviral therapy (cART) among patients receiving HIV care in Taiwan. Methods: We retrospectively reviewed the medical records of HIV-infected adult patients who initiated cART at 11 designated hospitals in Taiwan between 2012 and 2016. The clinical information collected included serological profiles on HBV, hepatitis C virus (HCV), and syphilis, plasma HIV RNA load, nadir CD4 cell count, and antiretrovirals with activity against both HBV and HIV (tenofovir disoproxil fumarate [TDF], lamivudine [LAM], and emtricitabine [FTC]). Results: We analyzed 1800 HIV-infected patients; 1742 (96.8%) were male and 794 (44.1%) were born after July, 1986, when nationwide universal neonatal HBV vaccination was implemented. HBsAg positive results were 11.6% (209/1800), which decreased significantly from 18.1% (182/1006) in those born before July 1986 to 3.4% (27/794) in those born after. In multi variable analysis, HBsAg positivity was significantly associated with age (adjusted odds ratio [aOR] 1.06, 95% confidence interval [CI] 1.05-1.08), CD4S200 cells/mL (aOR 0.73, 95% CI 0.53-0.99), and HCV seropositivity (aOR 1.62, 95% CI 1.06-2.50 ). Of 209 HBV/HIVcoinfected patients, 31.1% started cART containing only LAM with anti-HBV activity, while 68.9% started cART containing TDF plus LAM or coformulated TDF/FTC. Conclusions: The overall prevalence of HBV/HIV coinfection remained high among HIV infected patients in Taiwan. Despite recommendations of the HIV treatment guidelines for the management of HBV infection, a substantial proportion of HIV/HBV-coinfected patients received cART containing only LAM for HBV infection. Copyright & ordf; 2019, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
關聯:	J MICROBIOL IMMUNOL, v.54, n.2, pp.228-237
顯示於類別:	[保健營養系(所) ] 期刊論文

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