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    標題: Stereotactic radiosurgery for central neurocytomas: an international multicenter retrospective cohort study
    作者: Hung, Yi-Chieh
    Lee, Cheng-Chia
    Yang, Huai-che
    Mohammed, Nasser
    Kearns, Kathryn N.
    Sun, Shi-Bin
    Mathieu, David
    Touchette, Charles J.
    Atik, Ahmet F.
    Grills, Inga S.
    Squires, Bryan
    Ding, Dale
    Williams, Brian J.
    Yusuf, Mehran B.
    Woo, Shiao Y.
    Liscak, Roman
    Hanuska, Jaromir
    Shiao, Jay C.
    Kondziolka, Douglas
    Lunsford, L. Dade
    Xu, Zhiyuan
    Sheehan, Jason P.
    貢獻者: Univ Virginia Hlth Syst, Dept Neurol Surg, Charlottesville
    Chi Mei Med Ctr, Dept Neurosurg, Dept Surg
    Chia Nan Univ Pharm & Sci, Dept Recreat & Healthcare Management
    Taipei Vet Gen Hosp, Neurol Inst, Dept Neurosurg
    Natl Yang Ming Univ, Sch Med
    Capital Univ Med Sci, Beijing Neurosurg Inst, Beijing Tiantan Hosp, Gamma Knife Ctr
    Univ Sherbrooke, Ctr Rech, Ctr Hosp Univ Sherbrooke, Quebec City
    Cleveland Clin Fdn, Dept Neurosurg, Cleveland
    William Beaumont Hosp, Dept Radiat Oncol, Royal Oak
    Univ Louisville, Dept Neurosurg, Louisville
    Univ Louisville, Dept Radiat Oncol, Louisville
    Homolce Hosp, Dept Stereotact & Radiat Neurosurg, Prague
    Homolce Hosp, Dept Neurosurg, Prague
    Univ Colorado, Ctr Canc, Dept Radiat Oncol, Aurora, CO USA;[Kondziolka, Douglas
    NYU Langone Hlth Syst, Dept Neurosurg
    Univ Pittsburgh, Dept Neurosurg, Pittsburgh
    關鍵字: central neurocytoma
    Gamma Knife radiosurgery
    stereotactic radiosurgery
    intracranial neoplasms
    日期: 2021
    上傳時間: 2023-11-11 11:53:14 (UTC+8)
    出版者: AMER ASSOC NEUROLOGICAL SURGEONS
    摘要: OBJECTIVE Central neurocytomas (CNs) are uncommon intraventricular tumors, and their rarity renders the risk-to-benefit profile of stereotactic radiosurgery (SRS) unknown. The aim of this multicenter, retrospective cohort study was to evaluate the outcomes of SRS for CNs and identify predictive factors. METHODS The authors retrospectively analyzed a cohort of patients with CNs treated with SRS at 10 centers between 1994 and 2018. Tumor recurrences were classified as local or distant. Adverse radiation effects (AREs) and the need for a CSF shunt were also evaluated. RESULTS The study cohort comprised 60 patients (median age 30 years), 92% of whom had undergone prior resection or biopsy and 8% received their diagnosis based on imaging alone. The median tumor volume and margin dose were 5.9 cm(3) and 13 Gy, respectively. After a median clinical follow-up of 61 months, post-SRS tumor recurrence occurred in 8 patients (13%). The 5- and 10-year local tumor control rates were 93% and 87%, respectively. The 5- and 10-year progression-free survival rates were 89% and 80%, respectively. AREs were observed in 4 patients (7%), but only 1 was symptomatic (2%). Two patients underwent post-SRS tumor resection (3%). Prior radiotherapy was a predictor of distant tumor recurrence (p = 0.044). Larger tumor volume was associated with pre-SRS shunt surgery (p = 0.022). CONCLUSIONS Treatment of appropriately selected CNs with SRS achieves good tumor control rates with a reasonable complication profile. Distant tumor recurrence and dissemination were observed in a small proportion of patients, which underscores the importance of close post-SRS surveillance of CN patients. Patients with larger CNs are more likely to require shunt surgery before SRS.
    關聯: J NEUROSURG, v.134, n.4, pp.1122-1131
    Appears in Collections:[休閒保健管理系(所)] 期刊論文

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