Increased Risk of Congestive Heart Failure Following Carbon Monoxide Poisoning

doi:10.1161/CIRCHEARTFAILURE.120.007267

Chia Nan University of Pharmacy & Science Institutional Repository > 智慧生活學院 > 醫務管理系(所) > 期刊論文 > Item 310902800/34444

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34444

標題:	Increased Risk of Congestive Heart Failure Following Carbon Monoxide Poisoning
作者:	Huang, Chien-Cheng Chen, Tzu-Hao Ho, Chung-Han Chen, Yi-Chen Hsu, Chien-Chin Lin, Hung-Jung Wang, Jhi-Joung Chang, Ching-Ping Guo, How-Ran
貢獻者:	Chi Mei Med Ctr, Dept Emergency Med Chi Mei Med Ctr, Dept Med Res Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth Southern Taiwan Univ Sci & Technol, Dept Senior Serv Southern Taiwan Univ Sci & Technol, Dept Biotechnol Southern Taiwan Univ Sci & Technol, Allied AI Biomed Ctr Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Taipei Med Univ, Dept Emergency Med Natl Cheng Kung Univ, Dept Occupat & Environm Med Natl Cheng Kung Univ, Occupat Safety Hlth & Med Res Ctr
關鍵字:	animals carbon monoxide poisoning echocardiography epidemiology heart failure
日期:	2021
上傳時間:	2023-11-11 11:53:08 (UTC+8)
出版者:	LIPPINCOTT WILLIAMS & WILKINS
摘要:	Background: Carbon monoxide poisoning (COP) is an important public health issue around the world. It may increase the risk of myocardial injury, but the association between COP and congestive heart failure (CHF) remains unclear. We conducted a study incorporating data from epidemiological and animal studies to clarify this issue. Methods: Using the National Health Insurance Database of Taiwan, we identified patients with COP diagnosed between 1999 and 2012 and compared them with patients without COP (non-COP cohort) matched by age and the index date at a 1:3 ratio. The comparison for the risk of CHF between the COP and non-COP cohorts was made using Cox proportional hazards regression. We also established a rat model to evaluate cardiac function using echocardiography and studied the pathological changes following COP. Results: The 20 942 patients in the COP cohort had a higher risk for CHF than the 62 826 members in the non-COP cohort after adjusting for sex and underlying comorbidities (adjusted hazard ratio, 2.01 [95% CI, 1.74-2.32]). The increased risk of CHF persisted even after 2 years of follow-up (adjusted hazard ratio, 1.85 [95% CI, 1.55-2.21]). In the animal model, COP led to a decreased left ventricular ejection fraction on echocardiography and damage to cardiac cells with remarkable fibrotic changes. Conclusions: Our epidemiological data showed an increased risk of CHF was associated with COP, which was supported by the animal study. We suggest close follow-up of cardiac function for patients with COP to facilitate early intervention and further studies to identify other long-term effects that have not been reported in the literature.
關聯:	CIRC-HEART FAIL, v.14, n.4, pp.e007267
显示于类别:	[醫務管理系(所)] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
CIRCHEARTFAILURE.120.007267.pdf		2503Kb	Adobe PDF	84	检视/开启
index.html		0Kb	HTML	208	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....