The Fibronectin Expression Determines the Distinct Progressions of Malignant Gliomas via Transforming Growth Factor-Beta Pathway

doi:10.3390/ijms22073782

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Title:	The Fibronectin Expression Determines the Distinct Progressions of Malignant Gliomas via Transforming Growth Factor-Beta Pathway
Authors:	Chen, Chih-Wei Yang, Cheng-Han Lin, Yuan-Ho Hou, Ya-Chin Cheng, Tain-Junn Chang, Sheng-Tsung Huang, Yu-Hua Chung, Shang-Ting Chio, Chung-Ching Shan, Yan-Shen Cheng, Hung-Chi Chang, Wen-Tsan
Contributors:	Natl Cheng Kung Univ, Coll Med, Inst Clin Med Chi Mei Fdn Med Ctr, Dept Surg, Div Neurosurg Chia Nan Univ Pharm & Sci, Coll Sustainable Environm, Dept Occupat Safety & Hlth, Inst Ind Safety & Disaster Prevent Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci Chi Mei Fdn Med Ctr, Dept Neurol & Occupat Med Chi Mei Fdn Med Ctr, Dept Pathol Chi Mei Fdn Med Ctr, Dept Nursing Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol Natl Cheng Kung Univ, Coll Med, Dept Surg, Div Gen Surg
Keywords:	glioma glioblastoma multiforme (GBM) tumor recurrence tumor metastasis epithelial-mesenchymal transition (EMT) fibronectin (FN) vimentin (VIM) transforming growth factor-beta (TGF-946 )
Date:	2021
Issue Date:	2023-11-11 11:52:58 (UTC+8)
Publisher:	MDPI
Abstract:	Due to the increasing incidence of malignant gliomas, particularly glioblastoma multiforme (GBM), a simple and reliable GBM diagnosis is needed to screen early the death-threaten patients. This study aimed to identify a protein that can be used to discriminate GBM from low-grade astrocytoma and elucidate further that it has a functional role during malignant glioma progressions. To identify proteins that display low or no expression in low-grade astrocytoma but elevated levels in GBM, glycoprotein fibronectin (FN) was particularly examined according to the mining of the Human Protein Atlas. Web-based open megadata minings revealed that FN was mainly mutated in the cBio Cancer Genomic Portal but dominantly overexpressed in the ONCOMINE (a cancer microarray database and integrated data-mining platform) in distinct tumor types. Furthermore, numerous different cancer patients with high FN indeed exhibited a poor prognosis in the PrognoScan mining, indicating that FN involves in tumor malignancy. To investigate further the significance of FN expression in glioma progression, tumor specimens from five malignant gliomas with recurrences that received at least two surgeries were enrolled and examined. The immunohistochemical staining showed that FN expression indeed determined the distinct progressions of malignant gliomas. Furthermore, the expression of vimentin (VIM), a mesenchymal protein that is strongly expressed in malignant cancers, was similar to the FN pattern. Moreover, the level of epithelial-mesenchymal transition (EMT) inducer transforming growth factor-beta (TGF-beta) was almost recapitulated with the FN expression. Together, this study identifies a protein FN that can be used to diagnose GBM from low-grade astrocytoma; moreover, its expression functionally determines the malignant glioma progressions via TGF-beta-induced EMT pathway.
Relation:	INT J MOL SCI, v.22, n.7, pp.3782
Appears in Collections:	[Indoor Air Qual Res & Serv Ctr] Periodical Articles

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