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| 標題: | The risk of pulmonary tuberculosis after traumatic brain injury |
| 作者: | Liu, Hsin-Yueh
Liao, Kuang-Ming
Liang, Fu-Wen
Hung, Yi-Chieh
Wang, Jhi-Joung
Shen, Te-Chun
Ho, Chung-Han |
| 貢獻者: | Chi Mei Med Ctr, Dept Internal Med
Kaohsiung Med Univ, Coll Hlth Sci, Dept Publ Hlth
Kaohsiung Med Univ Hosp, Dept Med Res
Kaohsiung Med Univ, Res Ctr Environm Med
Chi Mei Med Ctr, Dept Surg, Dept Neurosurg
Chia Nan Univ Pharm & Sci, Dept Recreat & Healthcare Management
Chi Mei Med Ctr, Dept Med Res
Chi Mei Med Ctr, Dept Anesthesiol
Southern Taiwan Univ Sci & Technol, AI Biomed Ctr
China Med Univ, Sch Med
China Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:52:49 (UTC+8) |
| 出版者: | NATURE RESEARCH |
| 摘要: | After traumatic brain injury (TBI), an inflammatory response in the brain might affect the immune system. The risk of pulmonary infection reportedly increases in patients with TBI. We aimed to evaluate the risk of tuberculosis (TB) in patients with TBI in Taiwan. All participants were selected from the intensive care unit (ICU). Patients with TBI were defined as patients in ICU with intracranial injury, and comparison cohort were patients in ICU without TBI diagnosis. There was a significant difference in TB risk between the patients with TBI and the comparison cohort according to age and the Charlson's comorbidity index (CCI) score. Thus, we divided patients based on CCI into three groups for further analysis: mild (CCI = 0), moderate (CCI = 1/2), severe (CCI > 2). Mild-CCI group had a lower TB incidence rate (0.74%) and longer time to TB development (median: 2.43) than the other two groups. Moderate-CCI group had 1.52-fold increased risk of TB infection (p < 0.0001) compared with mild-CCI group. In the severe-CCI group, patients aged >= 80 years had 1.91-fold risk of TB compared with mild-CCI group (p = 0.0481). Severe-CCI group had significantly higher mortality than the mild-CCI group (p = 0.0366). Patients with TBI and more comorbidities had higher risk of TB infection with higher mortality rate. |
| 關聯: | SCI REP-UK, v.11, n.1, pp.7840 |
| 顯示於類別: | [休閒保健管理系(所)] 期刊論文
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