Feasibility of anti-HCV reflex HCV Ag screening strategy in an HCV endemic community

doi:10.1016/j.jfma.2020.09.013

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/34436

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34436

Title:	Feasibility of anti-HCV reflex HCV Ag screening strategy in an HCV endemic community
Authors:	Chen, Wei-Ming Lee, Chih-Yi Hsu, Nien-Tzu Huang, Wei-Cheng Chen, Mei-Yen Huang, Tung-Jung Lu, Sheng-Nan
Contributors:	Chang Gung Mem Hosp, Dept Internal Med, Div Gastroenterol & Hepatol Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chang Gung Univ, Sch Med, Coll Med Chang Gung Mem Hosp, Dept Lab Med Kaohsiung Chang Gung Mem Hosp, Biostat & Bioinformat Ctr Chang Gung Mem Hosp, Dept Geriatr Chang Gung Univ Sci & Technol, Dept Nursing Chang Gung Mem Hosp, Dept Pulm Dis & Crit Care
Keywords:	Anti-HCV reflex HCV Ag screening HCV Ag HCV screening
Date:	2021
Issue Date:	2023-11-11 11:52:39 (UTC+8)
Publisher:	ELSEVIER TAIWAN
Abstract:	Background/Purpose: The HCV core antigen (HCV Ag) assay displays high sensitivity and strong correlation with HCV RNA. However, the feasibility of anti-HCV reflex HCV Ag screening in a community-wide setting is rarely discussed. Methods: We performed a two-phase community-based hepatitis C screen in an HCV-prone area of central Taiwan. During the training phase, all participants were test for anti-HCV, HCV Ag and HCV RNA to validate sensitivity, specificity, and accuracy of HCV Ag. During the validation phase, an anti-HCV reflex HCV Ag screen was conducted based on the results of training phase. Outcomes of the study were presented as positive and negative predictive values (PPV and NPV). Results: Of 935 training phase participants, the rate of positive anti-HCV and HCV Ag were 175 (18.7%) and 78 (8.3%), respectively. Test sensitivity, specificity, and accuracy of HCV Ag were 97.1%, 98.6%, and 97.8%, respectively. During validation phase, only anti-HCV-positive serum samples were tested for HCV Ag. Of 1932 participant, 285 (14.8%) were anti-HCV-positive. 133 (46.7%) of the 285 anti-HCV-positive samples were HCV Ag-positive. PPV and NPV were 98.4% and 99.3%, respectively. Across the entire participant sample, a significant linear correlation between HCV Ag and HCV RNA concentration was noted (r(2) = 0.93, p-value<0.0 01) following log-log transformation. Conclusion: Anti-HCV reflex HCV Ag screening is a feasible strategy for aiding HCV-prone communities. Copyright (C) 2020, Formosan Medical Association. Published by Elsevier Taiwan LLC.
Relation:	J FORMOS MED ASSOC, v.120, n.5, pp.1237-1241
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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