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| 標題: | Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-kappa B Signaling Pathway and NLRP3 Inflammasome Activation |
| 作者: | Huang, Chi-Han
Wang, Shu-Chi
Chen, I-Chen
Chen, Yi-Ting
Liu, Po-Len
Fang, Shih-Hua
Huang, Shu-Pin
Yeh, Hsin-Chih
Liu, Ching-Chih
Lee, Po-Yen
Lin, Tzu-Chieh
Cheng, Wei-Chung
Su, Chia-Cheng
Wu, Hsin-En
Chen, Yuan-Ru
Li, Chia-Yang |
| 關鍵字: | piplartine
macrophage
inflammation
NLRP3 inflammasome
sepsis |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:50:34 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Piplartine (or Piperlongumine) is a natural alkaloid isolated from Piper longum L., which has been proposed to exhibit various biological properties such as anti-inflammatory effects; however, the effect of piplartine on sepsis has not been examined. This study was performed to examine the anti-inflammatory activities of piplartine in vitro, ex vivo and in vivo using murine J774A.1 macrophage cell line, peritoneal macrophages, bone marrow-derived macrophages and an animal sepsis model. The results demonstrated that piplartine suppresses iNOS and COX-2 expression, reduces PGE(2), TNF-alpha and IL-6 production, decreases the phosphorylation of MAPKs and NF-kappa B and attenuates NF-kappa B activity by LPS-activated macrophages. Piplartine also inhibits IL-1 beta production and suppresses NLRP3 inflammasome activation by LPS/ATP- and LPS/nigericin-activated macrophages. Moreover, piplartine reduces the production of nitric oxide (NO) and TNF-alpha, IL-6 and IL-1 beta, decreases LPS-induced tissue damage, attenuates infiltration of inflammatory cells and enhances the survival rate. Collectively, these results demonstrate piplartine exhibits anti-inflammatory activities in LPS-induced inflammation and sepsis and suggest that piplartine might have benefits for sepsis treatment. |
| 關聯: | PHARMACEUTICALS-BASE, v.14, n.6 |
| 顯示於類別: | [高齡福祉養生管理系] 期刊論文
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