Is Behcet's syndrome associated with an increased risk of ischemic heart disease? A real-world evidence in Taiwan

doi:10.1186/s13075-021-02543-6

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Title:	Is Behcet's syndrome associated with an increased risk of ischemic heart disease? A real-world evidence in Taiwan
Authors:	Lin, Chun-Yu Chen, Hung-An Wu, Chun-Hsin Su, Yu-Jih Hsu, Tsai-Ching Hsu, Chung-Yuan
Contributors:	Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med,Div Rheumatol Chi Mei Med Ctr, Dept Internal Med, Div Allergy Immunol Rheumatol Chia Nan Univ Pharm & Sci Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med Chang Gung Mem Hosp, Dept Internal Med, Div Rheumatol Allergy & Immunol Chang Gung Univ, Coll Med Chung Shan Med Univ, Inst Biochem Microbiol & Immunol Chang Gung Univ, Dept Internal Med, Kaohsiung Chang Gung Mem Hosp, Div Rheumatol Allergy & Immunol,Coll Med
Keywords:	Behcet's syndrome Ischemic heart disease Long-term mortality
Date:	2021
Issue Date:	2023-11-11 11:50:31 (UTC+8)
Publisher:	BMC
Abstract:	BackgroundA variety of chronic inflammatory diseases are linked to ischemic heart disease (IHD); however, this association is less well studied in patients with Behcet's syndrome (BS). The primary objective of this study was to examine the impact of BS on the risk of IHD. The secondary objective was to estimate the long-term mortality risk in patients with BS.MethodsUsing a retrospective cohort design based on the Taiwan National Health Insurance Database, patients diagnosed with BS between 2000 and 2013, without prior history of IHD, were compared to non-BS individuals. The BS and non-BS cohorts were matched with a 1:2 ratio by propensity score, accounting for the following confounders: age, sex, year of index date, comorbidities, and drug exposure. Cox proportional hazard regression was used to derive the hazard ratio (HR) for IHD and mortality. The long-term survival rate was estimated using the Kaplan-Meier method.ResultsAfter propensity score matching, a total of 1554 patients newly diagnosed with BS and 3108 control subjects were identified. The incidence rate of IHD in the BS and control groups was 2.7 and 2.9 per 1000 person-years, respectively. The risk of IHD was comparable between BS and control cohorts [adjusted HR, 1.03; 95% confidence interval (CI), 0.66 to 1.62]. The 5- and 10-year survival rate of BS patients was 96.8% and 95.0%, respectively. Patients with BS exhibited a significantly higher risk of mortality than the sex- and age-matched general population (adjusted HR, 1.73; 95% CI, 1.30 to 2.32).ConclusionUnlike other chronic systemic autoimmune disorders, BS does not appear to be associated with an excess risk of IHD.
Relation:	ARTHRITIS RES THER, v.23, n.1
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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