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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34403


    標題: The risk of major bleeding event in patients with chronic kidney disease on pentoxifylline treatment
    作者: Fang, Jing-Hung
    Chen, Yi-Chen
    Ho, Chung-Han
    Chen, Jui-Yi
    Hsing, Chung-Hsi
    Liang, Fu-Wen
    Wu, Chia-Chun
    貢獻者: Chi Mei Med Ctr, Dept Nephrol
    Chi Mei Med Ctr, Dept Med Res
    Chi Mei Med Ctr, Dept Anaesthesiol
    Kaohsiung Med Univ, Coll Hlth Sci, Dept Publ Hlth
    Kaohsiung Med Univ Hosp, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Pharm
    關鍵字: RETROSPECTIVE-COHORT
    ASPIRIN
    HEMORRHAGE
    WOMEN
    SCORE
    MEN
    日期: 2021
    上傳時間: 2023-11-11 11:49:58 (UTC+8)
    出版者: NATURE RESEARCH
    摘要: Patients with chronic kidney diseases (CKD) are often treated with antiplatelets due to aberrant haemostasis. This study aimed to evaluate the bleeding risk with CKD patients undergoing pentoxifylline (PTX) treatment with/without aspirin. In this retrospective study, we used Taiwan's National Health Insurance Research Database to identify PTX treated CKD patients. Patients undergoing PTX treatment after CKD diagnosis were PTX group. A 1:4 age, sex and aspirin used condition matched CKD patients non-using PTX were identified as controls. The outcome was major bleeding event (MBE: intracranial haemorrhage (ICH) and gastrointestinal tract bleeding) during 2-year follow-up period. Risk factors were estimated using Cox regression for overall and stratified analysis. The PTX group had higher MBE risk than controls (hazard ratio (HR) 1.19; 95% confidence interval (CI) 0.94-1.50). In stratified analysis, hyperlipidaemia was a significant risk factor (HR: 1.42; 95% CI 1.01-2.01) of MBE. A daily PTX dose larger than 800 mg, females, non-regular aspirin usage, and ischaemic stroke were risk factors for MBE in PTX group. When prescribing PTX in CKD patients, bleeding should be closely monitored, especially in those with daily dose more than 800 mg, aspirin users, and with a history of ischaemic stroke.
    關聯: SCI REP-UK, v.11, n.1
    Appears in Collections:[藥學系(所)] 期刊論文

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