Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials

doi:10.3390/cells10071629

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/34402

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题名:	Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials
作者:	Lin, Yu-Hsuan Lin, Yueh-Chien Chen, Chien-Chin
贡献者:	Natl Sun Yat Sen Univ, Inst Biomed Sci Kaohsiung Vet Gen Hosp, Dept Otolaryngol Head & Neck Surg Natl Yang Ming Chiao Tung Univ, Sch Med Chung Shan Med Univ, Sch Med Natl Taiwan Univ, Dept Life Sci Harvard Med Sch, Boston Childrens Hosp, Dept Surg, Vasc Biol Program Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
关键词:	antagonist cancer clinical trial lysophosphatidic acid lysophosphatidic receptor therapy
日期:	2021
上传时间:	2023-11-11 11:49:53 (UTC+8)
出版者:	MDPI
摘要:	Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled receptors, termed LPA receptors (LPAR1 to LPAR6). LPA signaling drives cell migration and proliferation, cytokine production, thrombosis, fibrosis, angiogenesis, and lymphangiogenesis. Since the expression and function of LPA receptors are critical for cellular effects, selective antagonists may represent a potential treatment for a broad range of illnesses, such as cardiovascular diseases, idiopathic pulmonary fibrosis, voiding dysfunctions, and various types of cancers. More new LPA receptor antagonists have shown their therapeutic potentials, although most are still in the preclinical trial stage. This review provided integrative information and summarized preclinical findings and recent clinical trials of different LPA receptor antagonists in cancer progression and resistance. Targeting LPA receptors can have potential applications in clinical patients with various diseases, including cancer.
關聯:	CELLS-BASEL, v.10, n.7, 1629
显示于类别:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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