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https://ir.cnu.edu.tw/handle/310902800/34402
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| Title: | Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials |
| Authors: | Lin, Yu-Hsuan
Lin, Yueh-Chien
Chen, Chien-Chin |
| Contributors: | Natl Sun Yat Sen Univ, Inst Biomed Sci
Kaohsiung Vet Gen Hosp, Dept Otolaryngol Head & Neck Surg
Natl Yang Ming Chiao Tung Univ, Sch Med
Chung Shan Med Univ, Sch Med
Natl Taiwan Univ, Dept Life Sci
Harvard Med Sch, Boston Childrens Hosp, Dept Surg, Vasc Biol Program
Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci |
| Keywords: | antagonist
cancer
clinical trial
lysophosphatidic acid
lysophosphatidic receptor
therapy |
| Date: | 2021 |
| Issue Date: | 2023-11-11 11:49:53 (UTC+8) |
| Publisher: | MDPI |
| Abstract: | Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled receptors, termed LPA receptors (LPAR1 to LPAR6). LPA signaling drives cell migration and proliferation, cytokine production, thrombosis, fibrosis, angiogenesis, and lymphangiogenesis. Since the expression and function of LPA receptors are critical for cellular effects, selective antagonists may represent a potential treatment for a broad range of illnesses, such as cardiovascular diseases, idiopathic pulmonary fibrosis, voiding dysfunctions, and various types of cancers. More new LPA receptor antagonists have shown their therapeutic potentials, although most are still in the preclinical trial stage. This review provided integrative information and summarized preclinical findings and recent clinical trials of different LPA receptor antagonists in cancer progression and resistance. Targeting LPA receptors can have potential applications in clinical patients with various diseases, including cancer. |
| Relation: | CELLS-BASEL, v.10, n.7, 1629 |
| Appears in Collections: | [Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles
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| cells10071629.pdf | | 1057Kb | Adobe PDF | 112 | View/Open | | index.html | | 0Kb | HTML | 408 | View/Open |
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