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| 標題: | Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study |
| 作者: | Chiu, Chong-Chi
Ho, Chung-Han
Hung, Chao-Ming
Chao, Chien-Ming
Lai, Chih-Cheng
Chen, Chin-Ming
Liao, Kuang-Ming
Wang, Jhi-Joung
Wu, Yu-Cih
Shi, Hon-Yi
Lee, Po-Huang
Lee, Hui-Ming
Yeh, Li-Ren
Soong, Tien-Chou
Chiang, Shyh-Ren
Cheng, Kuo-Chen |
| 貢獻者: | E Da Canc Hosp, Dept Gen Surg
I Shou Univ, Coll Med, Sch Med
Chi Mei Med Ctr, Dept Med Res
Taipei Med Univ, Wan Fang Hosp, Canc Ctr
Southern Taiwan Univ Sci & Technol, Dept Informat Management
I Shou Univ, Coll Med
Chi Mei Med Ctr, Dept Intens Care Med
Min Hwei Coll Hlth Care Management, Dept Dent Lab Technol
Kaohsiung Vet Gen Hosp, Dept Internal Med, Tainan Branch
Chi Mei Med Ctr, Dept Intens Care Med
Chi Mei Med Ctr, Dept Internal Med
Chi Mei Med Ctr, Dept Anesthesiol
Natl Def Med Ctr, Dept Anesthesiol
Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat, Kaohsiung 80708, Taiwan;[Shi, Hon-Yi
Natl Sun Yat Sen Univ, Dept Business Management
Kaohsiung Med Univ Hosp, Dept Med Res
China Med Univ, China Med Univ Hosp, Dept Med Res
E Da Hosp, Dept Surg
E Da Canc Hosp, Dept Anesthesiol
Shu Zen Jr Coll Med & Management, Dept Med Imaging & Radiol
E Da Dachang Hosp, Weight Loss & Hlth Management Ctr
Chi Mei Med Ctr, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Gen Educ
Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm |
| 關鍵字: | colorectal cancer
body mass index
oncologic prognosis
overall survival
disease-free survival
colorectal cancer-specific survival |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:49:47 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Simple Summary Obesity is related to the rising risk of colorectal cancer (CRC). However, the impact of body mass index (BMI) on the oncologic prognosis of CRC patients remains unknown. Conflicting results regarding the relationship between BMI and CRC prognosis have been reported. Therefore, we conducted a nationwide retrospective study that examined the correlation of BMI at diagnosis with overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients. We noted that an underweight status at diagnosis was related to higher mortality and recurrence rates, a decreased rate of OS, and a decreased CRC-specific survival rate compared with those for the normal weight patients. In contrast, overweight and class I or II obese patients had better OS, CRC-specific survival, and DFS rates than those in the normal weight category. Our findings suggest that weight loss in the immediate diagnosis period is unwarranted. It has been acknowledged that excess body weight increases the risk of colorectal cancer (CRC); however, there is little evidence on the impact of body mass index (BMI) on CRC patients' long-term oncologic results in Asian populations. We studied the influence of BMI on overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients from the administrative claims datasets of Taiwan using the Kaplan-Meier survival curves and the log-rank test to estimate the statistical differences among BMI groups. Underweight patients (<18.50 kg/m(2)) presented higher mortality (56.40%) and recurrence (5.34%) rates. Besides this, they had worse OS (aHR:1.61; 95% CI: 1.53-1.70; p-value: < 0.0001) and CRC-specific survival (aHR:1.52; 95% CI: 1.43-1.62; p-value: < 0.0001) rates compared with those of normal weight patients (18.50-24.99 kg/m(2)). On the contrary, CRC patients belonging to the overweight (25.00-29.99 kg/m(2)), class I obesity (30.00-34.99 kg/m(2)), and class II obesity (>= 35.00 kg/m(2)) categories had better OS, DFS, and CRC-specific survival rates in the analysis than the patients in the normal weight category. Overweight patients consistently had the lowest mortality rate after a CRC diagnosis. The associations with being underweight may reflect a reverse causation. CRC patients should maintain a long-term healthy body weight. |
| 關聯: | CANCERS, v.13, n.14 |
| 顯示於類別: | [通識教育中心] 期刊論文
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