English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18054/20253 (89%)
Visitors : 24244080      Online Users : 375
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34400


    標題: Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study
    作者: Chiu, Chong-Chi
    Ho, Chung-Han
    Hung, Chao-Ming
    Chao, Chien-Ming
    Lai, Chih-Cheng
    Chen, Chin-Ming
    Liao, Kuang-Ming
    Wang, Jhi-Joung
    Wu, Yu-Cih
    Shi, Hon-Yi
    Lee, Po-Huang
    Lee, Hui-Ming
    Yeh, Li-Ren
    Soong, Tien-Chou
    Chiang, Shyh-Ren
    Cheng, Kuo-Chen
    貢獻者: E Da Canc Hosp, Dept Gen Surg
    I Shou Univ, Coll Med, Sch Med
    Chi Mei Med Ctr, Dept Med Res
    Taipei Med Univ, Wan Fang Hosp, Canc Ctr
    Southern Taiwan Univ Sci & Technol, Dept Informat Management
    I Shou Univ, Coll Med
    Chi Mei Med Ctr, Dept Intens Care Med
    Min Hwei Coll Hlth Care Management, Dept Dent Lab Technol
    Kaohsiung Vet Gen Hosp, Dept Internal Med, Tainan Branch
    Chi Mei Med Ctr, Dept Intens Care Med
    Chi Mei Med Ctr, Dept Internal Med
    Chi Mei Med Ctr, Dept Anesthesiol
    Natl Def Med Ctr, Dept Anesthesiol
    Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat, Kaohsiung 80708, Taiwan;[Shi, Hon-Yi
    Natl Sun Yat Sen Univ, Dept Business Management
    Kaohsiung Med Univ Hosp, Dept Med Res
    China Med Univ, China Med Univ Hosp, Dept Med Res
    E Da Hosp, Dept Surg
    E Da Canc Hosp, Dept Anesthesiol
    Shu Zen Jr Coll Med & Management, Dept Med Imaging & Radiol
    E Da Dachang Hosp, Weight Loss & Hlth Management Ctr
    Chi Mei Med Ctr, Dept Internal Med
    Chia Nan Univ Pharm & Sci, Dept Gen Educ
    Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm
    關鍵字: colorectal cancer
    body mass index
    oncologic prognosis
    overall survival
    disease-free survival
    colorectal cancer-specific survival
    日期: 2021
    上傳時間: 2023-11-11 11:49:47 (UTC+8)
    出版者: MDPI
    摘要: Simple Summary Obesity is related to the rising risk of colorectal cancer (CRC). However, the impact of body mass index (BMI) on the oncologic prognosis of CRC patients remains unknown. Conflicting results regarding the relationship between BMI and CRC prognosis have been reported. Therefore, we conducted a nationwide retrospective study that examined the correlation of BMI at diagnosis with overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients. We noted that an underweight status at diagnosis was related to higher mortality and recurrence rates, a decreased rate of OS, and a decreased CRC-specific survival rate compared with those for the normal weight patients. In contrast, overweight and class I or II obese patients had better OS, CRC-specific survival, and DFS rates than those in the normal weight category. Our findings suggest that weight loss in the immediate diagnosis period is unwarranted. It has been acknowledged that excess body weight increases the risk of colorectal cancer (CRC); however, there is little evidence on the impact of body mass index (BMI) on CRC patients' long-term oncologic results in Asian populations. We studied the influence of BMI on overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients from the administrative claims datasets of Taiwan using the Kaplan-Meier survival curves and the log-rank test to estimate the statistical differences among BMI groups. Underweight patients (<18.50 kg/m(2)) presented higher mortality (56.40%) and recurrence (5.34%) rates. Besides this, they had worse OS (aHR:1.61; 95% CI: 1.53-1.70; p-value: < 0.0001) and CRC-specific survival (aHR:1.52; 95% CI: 1.43-1.62; p-value: < 0.0001) rates compared with those of normal weight patients (18.50-24.99 kg/m(2)). On the contrary, CRC patients belonging to the overweight (25.00-29.99 kg/m(2)), class I obesity (30.00-34.99 kg/m(2)), and class II obesity (>= 35.00 kg/m(2)) categories had better OS, DFS, and CRC-specific survival rates in the analysis than the patients in the normal weight category. Overweight patients consistently had the lowest mortality rate after a CRC diagnosis. The associations with being underweight may reflect a reverse causation. CRC patients should maintain a long-term healthy body weight.
    關聯: CANCERS, v.13, n.14
    Appears in Collections:[通識教育中心] 期刊論文

    Files in This Item:

    File Description SizeFormat
    cancers13143592.pdf1908KbAdobe PDF39View/Open
    index.html0KbHTML118View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback