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    標題: Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia
    作者: Chen, Bao-Yu
    Lin, Jin-Jia
    Lu, Ming-Kun
    Tan, Hung-Pin
    Jang, Fong-Lin
    Lin, Sheng-Hsiang
    貢獻者: Natl Cheng Kung Univ, Coll Med, Inst Clin Med
    Chi Mei Med Ctr, Dept Psychiat
    Jianan Mental Hosp, Dept Hlth
    Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
    Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth
    Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth
    Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med
    關鍵字: NEURAL DEVELOPMENT
    MICRORNA
    DISORDERS
    VARIANT
    PATHOPHYSIOLOGY
    DYSREGULATION
    ASSOCIATION
    RELATIVES
    SYMPTOMS
    INSIGHTS
    日期: 2021
    上傳時間: 2023-11-11 11:49:29 (UTC+8)
    出版者: NATURE RESEARCH
    摘要: Early-onset schizophrenia (EOS) may have stronger familial aggregation and a more severe outcome than adult-onset schizophrenia (AOS). MicroRNA (miRNA) takes on dual roles as a genetic and epigenetic modulator, which may mediate the influence of genetic risk. Neurological soft signs (NSS) are neurological abnormalities that may be intermediate phenotypes or endophenotypes for schizophrenia. Our previous study found poorer performance on NSS tests from patients with EOS and their unaffected first-degree relatives. Thus, we aimed to identify a set of aberrant neurodevelopmental-related miRNAs that could serve as potential biomarkers for EOS or schizophrenia with NSS. This study included 215 schizophrenia patients (104 EOS and 111 AOS), 72 unaffected first-degree relatives, 31 patients with bipolar disorder, and 100 healthy controls. Differential expression analysis revealed that miR-137, miR-34b, and miR-34c were significantly up-regulated in patients with schizophrenia and their unaffected first-degree relatives compared to healthy controls. Receiver operating characteristic (ROC) analysis showed that the miR-137 expression signature could be used to discriminate between patients with EOS and healthy controls (AUC = 0.911). Additionally, miR-34b had the highest ability to discriminate between EOS and AOS (AUC = 0.810), which may indicate different aetiological pathways to disease onset. Moreover, miR-137 dysregulation was correlated with almost all NSS subscales (i.e., sensory integration, motor sequencing, etc.) and, when EOS patients with NSS, miR-137 expression discriminated these patients from healthy controls to a greater extent (AUC = 0.957). These findings support the potential for neurodevelopmental-related miRNAs to be used as indicators of vulnerability to EOS.
    關聯: NPJ SCHIZOPHR, v.7, n.1
    Appears in Collections:[生活保健科技系] 期刊論文

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