Prognostic Significance of ROR2 Expression in Patients with Urothelial Carcinoma

doi:10.3390/biomedicines9081054

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Title:	Prognostic Significance of ROR2 Expression in Patients with Urothelial Carcinoma
Authors:	Yeh, Cheng-Fa Chan, Ti-Chun Ke, Hung-Lung Chen, Tzu-Ju Wu, Li-Ching Lee, Hsiang-Ying Wei, Yu-Ching Wu, Wen-Jeng Li, Chien-Feng Li, Wei-Ming
Contributors:	Chi Mei Med Ctr, Div Gen Internal Med Chia Nan Univ Pharm & Sci, Dept Environm Engn & Sci Chi Mei Med Ctr, Dept Med Res Natl Hlth Res Inst, Natl Inst Canc Res Kaohsiung Med Univ Hosp, Dept Urol Kaohsiung Med Univ, Coll Med, Sch Med, Dept Urol Kaohsiung Municipal Tatung Hosp, Dept Urol Chi Mei Med Ctr, Dept Clin Pathol Kaohsiung Med Univ, Coll Med, Sch Med, Dept Pathol Kaohsiung Municipal Tatung Hosp, Dept Pathol Kaohsiung Med Univ, Ctr Liquid Biopsy & Cohort Res Minist Hlth & Welf Pingtung Hosp, Dept Urol
Keywords:	ROR2 bladder cancer upper tract urothelial carcinoma survival prognosis
Date:	2021
Issue Date:	2023-11-11 11:48:49 (UTC+8)
Publisher:	MDPI
Abstract:	We investigated the association of receptor tyrosine kinase-like orphan receptor 2 (ROR2) expression with clinicopathological features and oncologic outcomes in large urothelial carcinoma (UC) of the upper tract (UTUC) and urinary bladder (UBUC) cohorts. Through transcriptomic profiling of a published dataset (GSE31684), ROR2 was discovered to be the most upregulated gene during UC progression, focusing on the INK cascade (GO:0007254). Initially, the evaluation of ROR2 mRNA expression in 50 frozen UBUCs showed significantly upregulated levels in highstage UC. Moreover, high ROR2 immunoexpression significantly correlated with high tumor stage, high tumor grade, lymph node metastasis, and vascular invasion (all p < 0.05). In multivariate analysis, after adjusting for standard clinicopathological features, ROR2 expression status was an independent prognosticator of cancer-specific survival and metastasis-free survival in UTUC and UBUC (all p < 0.01). In the subgroup analysis, it also significantly predicted bladder tumor recurrence in non-muscle invasive UBUC. Furthermore, the GO enrichment analysis showed that fatty acid, monocarboxylic acid, carboxylic acid metabolic processes, negative regulation of neutrophil migration, and negative regulation of granulocyte and neutrophil chemotaxis were significantly enriched by ROR2 dysregulation. In conclusion, high ROR2 immunoexpression was associated with aggressive pathological characteristics in UC and independently predicted worse prognosis, suggesting it could play roles in clinical risk stratification and therapy decisions.
Relation:	BIOMEDICINES, v.9, n.8
Appears in Collections:	[Dept. of Environmental Engineering and Science (including master's program)] Periodical Articles

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