Constitutive Cytomorphologic Features of Medullary Thyroid Carcinoma Using Different Staining Methods

doi:10.3390/diagnostics11081396

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標題:	Constitutive Cytomorphologic Features of Medullary Thyroid Carcinoma Using Different Staining Methods
作者:	Liu, Chih-Yi Chen, Chien-Chin Bychkov, Andrey Agarwal, Shipra Zhu, Yun Hang, Jen-Fan Lai, Chiung-Ru Na, Hee Young Park, So Yeon Li, Weiwei Liu, Zhiyan Jain, Deepali Suzuki, Ayana Hirokawa, Mitsuyoshi Chia, Noel Nga, Min En Jitpasutham, Tikamporn Keelawat, Somboon Satoh, Shinya Gunawardena, Dilini Kumarasinghe, Priyanthi Jung, Chan Kwon Kakudo, Kennichi
貢獻者:	Sijhih Cathay Gen Hosp, Div Pathol Fu Jen Catholic Univ, Coll Med, Sch Med Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Kameda Med Ctr, Dept Pathol, Kamogawa Nagasaki Univ, Dept Pathol, Grad Sch Biomed Sci All India Inst Med Sci, Dept Pathol Jiangsu Inst Nucl Med, Dept Pathol Taipei Vet Gen Hosp, Dept Pathol & Lab Med Natl Yang Ming Chiao Tung Univ, Sch Med Seoul Natl Univ, Coll Med, Dept Pathol, Bundang Hosp Shandong Univ, Dept Pathol, Sch Basic Med Sci Shanghai Jiao Tong Univ, Dept Pathol Kuma Hosp, Dept Diagnost Pathol & Cytol, Kobe, Hyogo 6500011, Japan;[Chia, Noel;Nga, Min En Natl Univ Singapore Hosp, Dept Pathol Chulalongkorn Univ, Fac Med, Dept Pathol Yamashita Thyroid & Parathyroid Clin, Dept Endocrine Surg Univ Western Australia, Sch Pathol & Lab Med, Perth Catholic Univ Korea, Dept Hosp Pathol, Coll Med Izumi City Gen Hosp, Dept Pathol & Thyroid Dis Ctr, Izumi
關鍵字:	cytology fine-needle aspiration medullary thyroid carcinoma sensitivity specificity thyroid
日期:	2021
上傳時間:	2023-11-11 11:48:39 (UTC+8)
出版者:	MDPI
摘要:	(1) Background: Accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to a spectrum of cytomorphologic features. However, there is a scarcity of studies describing the cytomorphologic features as seen on fine-needle aspiration (FNA) smears prepared using different staining methods. (2) Methods: We performed a retrospective study on MTC cases with available FNA slides from 13 hospitals distributed across 8 Asia-Pacific countries. The differences in the constitutive cytomorphologic features of MTC with each cytopreparatory method were recorded. A comparative analysis of cytologic characteristics was carried out with appropriate statistical tests. (3) Results: Of a total of 167 MTC samples retrospectively recruited, 148 (88.6%) were interpreted as MTC/suspicious for MTC (S-MTC). The staining methods used were Papanicolaou, hematoxylin-eosin, and Romanowsky stains. Seven out of the eleven cytologic criteria can be readily recognized by all three cytopreparatory methods: high cellularity, cellular pleomorphism, plasmacytoid cells, round cells, dyshesive cells, salt-and-pepper chromatin, and binucleation or multinucleation. An accurate diagnosis was achieved in 125 (84.5%) of the 148 samples whose FNAs exhibited five or more atypical features. Conclusions: The present work is the first study on MTC to compare the morphological differences among the cytologic staining techniques. We investigated the constitutive features and the reliability of diagnostic parameters. A feasible scoring system based upon cytomorphologic data alone is proposed to achieve a high degree of diagnostic accuracy.
關聯:	DIAGNOSTICS, v.11, n.8
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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