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    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34377


    標題: Dual therapy with dolutegravir plus boosted protease inhibitor as maintenance or salvage therapy in highly experienced people living with HIV
    作者: Lee, Yu-Lin
    Lin, Kuan-Yin
    Cheng, Shu-Hsing
    Lu, Po-Liang
    Wang, Ning-Chi
    Ho, Mao-Wang
    Yang, Chia-Jui
    Liou, Bo-Huang
    Tang, Hung-Jen
    Huang, Shie-Shian
    Huang, Sung-Hsi
    Chen, Tun-Chieh
    Lin, Chi-Ying
    Lin, Shih-Ping
    Lee, Yuan-Ti
    Hung, Chien-Ching
    貢獻者: Changhua Christian Hosp, Dept Internal Med, Changhua
    Natl Chung Hsing Univ, Inst Genom & Bioinformat
    Chung Shan Med Univ, Sch Med
    Natl Taiwan Univ Hosp, Dept Med, Jin Shan Branch
    Taoyuan Gen Hosp, Dept Infect Dis, Minist Hlth & Welf
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med
    Kaohsiung Med Univ, Coll Med
    Triserv Gen Hosp, Natl Def Med Ctr, Dept Internal Med
    China Med Univ Hosp, Dept Internal Med
    Far Eastern Mem Hosp, Dept Internal Med
    Natl Yang Ming Chiao Tung Univ, Sch Med
    Hsinchu MacKay Mem Hosp, Dept Internal Med
    Chi Mei Med Ctr, Dept Internal Med
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Keelung Chang Gung Mem Hosp, Dept Internal Med
    Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch
    Natl Taiwan Univ, Dept Trop Med & Parasitol, Coll Med
    Kaohsiung Municipal Tung Hosp, Dept Internal Med
    Natl Taiwan Univ Hosp, Dept Internal Med, Yun Lin Branch
    Taichung Vet Gen Hosp, Dept Internal Med, Sect Infect Dis
    Chung Shan Med Univ Hosp, tDept Internal Med
    Natl Taiwan Univ Hosp, Dept Internal Med
    關鍵字: Integrase strand transfer inhibitor
    Two-drug regimen
    Antiretroviral resistance
    Weight gain
    Dyslipidaemia
    日期: 2021
    上傳時間: 2023-11-11 11:48:13 (UTC+8)
    出版者: ELSEVIER
    摘要: Real-world experience with dolutegravir (DTG) plus boosted protease inhibitor (bPI) as a two-drug regimen is limited for highly experienced HIV-positive patients with virological failure or intolerance to antiretroviral therapy. Patients receiving DTG plus bPI between September 2016 and June 2019 at 15 designated hospitals for HIV care in Taiwan were retrospectively included in this study. A standardised case record form was used to collect clinical data. The primary endpoint was virological response, defined as achieving or maintaining plasma HIV-RNA <50 copies/mL at Week 48. A total of 77 patients were included; 58 (75.3%) had documented genotypic resistance to 1-4 antiretroviral classes. The most commonly used PI was darunavir (87.0%; 67/77). Seven patients (9.1%) had no virological data at Week 48, including three with loss to follow-up, one severe hyperlipidaemia, one renal failure and cardiovascular disease, one superimposed HBV infection and one death from anal cancer. The virological response rate increased from 59.7% at baseline to 90.9% at Week 24 and 85.7% at Week 48. The only patient (1.3%) with virological failure at Week 48 had poor adherence and baseline low-level resistance to darunavir with resistance-associated mutations at M46L, I50V and V82A. Compared with baseline, mean total cholesterol increased by 20.1 mg/dL and weight by 2.8 kg at Week 48, while the estimated glomerular filtration rate decreased by 14.4 mL/min/1.73m(2) (both P < 0.05). We conclude that a two-drug regimen containing DTG plus bPI was effective in highly-experienced HIV-positive patients, but metabolic impact and weight gain should be closely monitored. (C) 2021 Published by Elsevier Ltd.
    關聯: INT J ANTIMICROB AG, v.58, n.3, pp.106403
    顯示於類別:[保健營養系(所) ] 期刊論文

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