Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34364
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    Title: Development and validation of a green and sustainable procedure for the preparation of Perilla frutescens extracts
    Authors: Wei, Ming-Chi
    Wang, Chia-Sui
    Liou, Rey-May
    Yang, Yu-Chiao
    Contributors: Chia Nan Univ Pharm & Sci, Dept Environm Engn & Sci
    Air Force Acad, Ctr Gen Educ, Sect Math & Phys Sci
    Kaohsiung Med Univ, Dept & Grad Inst Pharmacol
    Kaohsiung Med Univ Hosp, Dept Med Res
    Keywords: Perilla frutescens
    Rosmarinic acid
    Ultrasound-assisted supercritical carbondioxide extraction
    Mass transfer coefficients
    Theoretical solubility
    Thermodynamic parameters
    Date: 2021
    Issue Date: 2023-11-11 11:47:06 (UTC+8)
    Publisher: ELSEVIER SCI LTD
    Abstract: A procedure combining supercritical CO2 and ultrasound-assisted (USC-CO2) extraction was developed to obtain rosmarinic acid (RA)-rich extracts from Perilla frutescens. Based on extraction yields and efficiencies, USC-CO2 was considered the best extraction method among the methods studied for obtaining RA from P. frutescens. The constant extraction rate period and the falling extraction rate period for USC-CO2 extraction of P. frutescens were 45 and 96 min long, respectively, and they were significantly shorter than those of traditional SC-CO2 (TSC-CO2) extraction. Furthermore, mass transfer coefficients were derived using the Sovov ' a model for the fluid and solid phases from USC-CO2 extraction, with values of 9.752 x 10(-3) and 4.203 x 10(-3) min(-1), respectively, which were obviously higher than those for TSC-CO2 extraction. Consequently, the theoretical solubilities of RA in the supercritical solvents used in dynamic USC-CO2 and TSC-CO2 extractions were estimated and found to be well correlated using three density-based models.
    Relation: FOOD CHEM, v.369, pp.130929
    Appears in Collections:[Dept. of Environmental Engineering and Science (including master's program)] Periodical Articles

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