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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34359

    標題: Toxicity of amantadine hydrochloride on cultured bovine cornea endothelial cells
    作者: Lee, Po-Yen
    Lai, Yu-Hung
    Liu, Po-Len
    Liu, Ching-Chih
    Su, Chia-Cheng
    Chiu, Fang-Yen
    Cheng, Wei-Chung
    Hsu, Shiuh-Liang
    Cheng, Kai-Chun
    Chiu, Li-Yi
    Kao, Tzu-En
    Lin, Chia-Ching
    Chang, Yo-Chen
    Wang, Shu-Chi
    Li, Chia-Yang
    貢獻者: Kaohsiung Med Univ, Grad Inst Med, Coll Med
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Ophthalmol
    Kaohsiung Med Univ, Sch Med, Dept Ophthalmol, Coll Med
    Kaohsiung Med Univ, Dept Resp Therapy, Coll Med
    Chi Mei Med Ctr, Dept Ophthalmol
    Chi Mei Med Ctr, Div Urol, Dept Surg
    Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management
    China Med Univ, Grad Inst Biomed Sci
    China Med Univ, Res Ctr Tumor Med Sci
    China Med Univ, Drug Dev Ctr
    Kaohsiung Municipal Siaogang Hosp, Dept Ophthalmol
    Kaohsiung Municipal Tatung Hosp, Dept Ophthalmol
    Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol
    Kaohsiung Med Univ, Ctr Canc Res
    關鍵字: EDEMA
    日期: 2021
    上傳時間: 2023-11-11 11:46:46 (UTC+8)
    摘要: Amantadine hydrochloride (HCl) is commonly prescribed for treating influenza A virus infection and Parkinson's disease. Recently, several studies have indicated that the use of amantadine HCl is associated with corneal edema; however, the cytotoxic effect of amantadine HCl has not been investigated. In the present study, the effects of amantadine HCl on cell growth, proliferation, and apoptosis in bovine cornea endothelial cells, and in vitro endothelial permeability were examined. Results showed that lower doses of amantadine HCl do not affect cell growth (<= 20 mu M), whereas higher doses of amantadine HCl inhibits cell growth (>= 50 mu M), induces apoptosis (2000 mu M), increases sub-G1 phase growth arrest (2000 mu M), causes DNA damage (>= 1000 mu M), and induces endothelial hyperpermeability (>= 1000 mu M) in bovine cornea endothelial cells; additionally, we also found that amantadine HCl attenuates the proliferation (>= 200 mu M) and arrests cell cycle at G1 phase (>= 200 mu M) in bovine cornea endothelial cells. In the present study, we measured the cytotoxic doses of amantadine HCl on cornea endothelial cells, which might be applied in evaluating the association of corneal edema.
    關聯: SCI REP-UK, v.11, n.1, pp.18514
    Appears in Collections:[高齡福祉養生管理系] 期刊論文

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