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| 標題: | Toxicity of amantadine hydrochloride on cultured bovine cornea endothelial cells |
| 作者: | Lee, Po-Yen
Lai, Yu-Hung
Liu, Po-Len
Liu, Ching-Chih
Su, Chia-Cheng
Chiu, Fang-Yen
Cheng, Wei-Chung
Hsu, Shiuh-Liang
Cheng, Kai-Chun
Chiu, Li-Yi
Kao, Tzu-En
Lin, Chia-Ching
Chang, Yo-Chen
Wang, Shu-Chi
Li, Chia-Yang |
| 貢獻者: | Kaohsiung Med Univ, Grad Inst Med, Coll Med
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Ophthalmol
Kaohsiung Med Univ, Sch Med, Dept Ophthalmol, Coll Med
Kaohsiung Med Univ, Dept Resp Therapy, Coll Med
Chi Mei Med Ctr, Dept Ophthalmol
Chi Mei Med Ctr, Div Urol, Dept Surg
Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management
China Med Univ, Grad Inst Biomed Sci
China Med Univ, Res Ctr Tumor Med Sci
China Med Univ, Drug Dev Ctr
Kaohsiung Municipal Siaogang Hosp, Dept Ophthalmol
Kaohsiung Municipal Tatung Hosp, Dept Ophthalmol
Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol
Kaohsiung Med Univ, Ctr Canc Res |
| 關鍵字: | EDEMA
RIMANTADINE |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:46:46 (UTC+8) |
| 出版者: | NATURE PORTFOLIO |
| 摘要: | Amantadine hydrochloride (HCl) is commonly prescribed for treating influenza A virus infection and Parkinson's disease. Recently, several studies have indicated that the use of amantadine HCl is associated with corneal edema; however, the cytotoxic effect of amantadine HCl has not been investigated. In the present study, the effects of amantadine HCl on cell growth, proliferation, and apoptosis in bovine cornea endothelial cells, and in vitro endothelial permeability were examined. Results showed that lower doses of amantadine HCl do not affect cell growth (<= 20 mu M), whereas higher doses of amantadine HCl inhibits cell growth (>= 50 mu M), induces apoptosis (2000 mu M), increases sub-G1 phase growth arrest (2000 mu M), causes DNA damage (>= 1000 mu M), and induces endothelial hyperpermeability (>= 1000 mu M) in bovine cornea endothelial cells; additionally, we also found that amantadine HCl attenuates the proliferation (>= 200 mu M) and arrests cell cycle at G1 phase (>= 200 mu M) in bovine cornea endothelial cells. In the present study, we measured the cytotoxic doses of amantadine HCl on cornea endothelial cells, which might be applied in evaluating the association of corneal edema. |
| 關聯: | SCI REP-UK, v.11, n.1, pp.18514 |
| 顯示於類別: | [高齡福祉養生管理系] 期刊論文
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