Enzymatic Synthesis of Novel Vitexin Glucosides

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/34355

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题名:	Enzymatic Synthesis of Novel Vitexin Glucosides
作者:	Wu, Jiumn-Yih Wang, Tzi-Yuan Ding, Hsiou-Yu Zhang, Yun-Rong Lin, Shu-Yuan Chang, Te-Sheng
贡献者:	Natl Quemoy Univ, Dept Food Sci Acad Sinica, Biodivers Res Ctr Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Natl Univ Tainan, Dept Biol Sci & Technol
关键词:	glycoside hydrolase glycosyltransferase glycosylation vitexin glucoside
日期:	2021
上传时间:	2023-11-11 11:46:33 (UTC+8)
出版者:	MDPI
摘要:	Vitexin is a C-glucoside flavone that exhibits a wide range of pharmaceutical activities. However, the poor solubility of vitexin limits its applications. To resolve this limitation, two glycoside hydrolases (GHs) and four glycosyltransferases (GTs) were assayed for glycosylation activity toward vitexin. The results showed that BtGT_16345 from the Bacillus thuringiensis GA A07 strain possessed the highest glycosylation activity, catalyzing the conversion of vitexin into new compounds, vitexin-4 '-O-beta-glucoside (1) and vitexin-5-O-beta-glucoside (2), which showed greater aqueous solubility than vitexin. To our knowledge, this is the first report of vitexin glycosylation. Based on the multiple bioactivities of vitexin, the two highly soluble vitexin derivatives might have high potential for pharmacological usage in the future.
關聯:	MOLECULES, v.26, n.20, pp.6274
显示于类别:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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