The Association of Ovarian Teratoma and Anti-N-Methyl-D-Aspartate Receptor Encephalitis: An Updated Integrative Review

doi:10.3390/ijms222010911

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34354

Title:	The Association of Ovarian Teratoma and Anti-N-Methyl-D-Aspartate Receptor Encephalitis: An Updated Integrative Review
Authors:	Wu, Cheng-Yang Wu, Jiann-Der Chen, Chien-Chin
Contributors:	Chung Shan Med Univ, Sch Med Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Keywords:	anti-N-methyl-D-aspartate receptor encephalitis autoantibody encephalitis germ cell tumor ovarian teratoma ovary paraneoplastic neurological syndrome teratoma
Date:	2021
Issue Date:	2023-11-11 11:46:24 (UTC+8)
Publisher:	MDPI
Abstract:	Ovarian teratomas are by far the most common ovarian germ cell tumor. Most teratomas are benign unless a somatic transformation occurs. The designation of teratoma refers to a neoplasm that differentiates toward somatic-type cell populations. Recent research shows a striking association between ovarian teratomas and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, a rare and understudied paraneoplastic neurological syndrome (PNS). Among teratomas, mature teratomas are thought to have a greater relevance with those neurological impairments. PNS is described as a neurologic deficit triggered by an underlying remote tumor, whereas anti-NMDAR encephalitis is characterized by a complex neuropsychiatric syndrome and the presence of autoantibodies in cerebral spinal fluid against the GluN1 subunit of the NMDAR. This review aims to summarize recent reports on the association between anti-NMDAR encephalitis and ovarian teratoma. In particular, the molecular pathway of pathogenesis and the updated mechanism and disease models would be discussed. We hope to provide an in-depth review of this issue and, therefore, to better understand its epidemiology, diagnostic approach, and treatment strategies.</p>
Relation:	INT J MOL SCI, v.22, n.20, pp.10911
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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