The new SRS/FSRT technique HyperArc for benign brain lesions: a dosimetric analysis

doi:10.1038/s41598-021-00381-9

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Title:	The new SRS/FSRT technique HyperArc for benign brain lesions: a dosimetric analysis
Authors:	Ho, Hsiu-Wen Yang, Ching-Chieh Lin, Hsiu-Man Chen, Hsiao-Yun Huang, Chun-Chiao Wang, Shih-Chang Lin, Yu-Wei
Contributors:	Chi Mei Med Ctr, Dept Radiat Oncol Chia Nan Univ Pharm & Sci, Dept Pharm Natl Cheng Kung Univ Hosp, Dept Radiat Oncol Kaohsiung Vet Gen Hosp, Dept Radiat Oncol
Keywords:	VOLUMETRIC-MODULATED ARC BODY RADIATION-THERAPY HYPOFRACTIONATED STEREOTACTIC RADIOTHERAPY GAMMA-KNIFE RADIOSURGERY VESTIBULAR SCHWANNOMAS PLAN QUALITY CONFORMITY METASTASES COLLIMATOR EFFICACY
Date:	2021
Issue Date:	2023-11-11 11:44:55 (UTC+8)
Publisher:	NATURE PORTFOLIO
Abstract:	To evaluate the potential benefit of HyperArc (HA) fractionated stereotactic radiotherapy (FSRT) for the benign brain lesion. Sixteen patients with a single deep-seated, centrally located benign brain lesion treated by CyberKnife (CK, G4 cone-based model) were enrolled. Treatment plans for HA with two different optimization algorithms (SRS NTO and ALDO) and coplanar RapidArc (RA) were generated for each patient to meet the corresponding treatment plan criteria. These four FSRT treatment plans were divided into two groups-the homogeneous delivery group (HA-SRS NTO and coplanar RA) and the inhomogeneous delivery group (HA-ALDO and cone-based CK)-to compare for dosimetric outcomes. For homogeneous delivery, the brain V5, V12, and V24 and the mean brainstem dose were significantly lower with the HA-SRS NTO plans than with the coplanar RA plans. The conformity index, high and intermediate dose spillage, and gradient radius were significantly better with the HA-SRS NTO plans than with the coplanar RA plans. For inhomogeneous delivery, the HA-ALDO exhibited superior PTV coverage levels to the cone-based CK plans. Almost all the doses delivered to organs at risk and dose distribution metrics were significantly better with the HA-ALDO plans than with the cone-based CK plans. Good dosimetric distribution makes HA an attractive FSRT technique for the treatment of benign brain lesions.
Relation:	SCI REP-UK, v.11, n.1, pp.21029
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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