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| 標題: | Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival |
| 作者: | Li, Wan-Shan
Chen, Chih-, I
Chen, Hsin-Pao
Liu, Kuang-Wen
Tsai, Chia-Jen
Yang, Ching-Chieh |
| 貢獻者: | Natl Sun Yat Sen Univ, Inst Biomed Sci
Chi Mei Med Ctr, Dept Pathol
Chung Hwa Univ Med Technol, Dept Med Technol
E DA Hosp, Dept Surg, Div Colon & Rectal Surg
E DA Hosp, Dept Surg, Div Gen Med Surg
I Shou Univ, Sch Med, Dept Med
I Shou Univ, Dept Informat Engn
I Shou Univ, Sch Chinese Med Post Baccalaureate
Chi Mei Med Ctr, Dept Radiat Oncol
Chia Nan Univ Pharm & Sci, Dept Pharm |
| 關鍵字: | melanophilin
rectal cancer
chemoradiotherapy
response
survival |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:44:44 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Data mining of a public transcriptomic rectal cancer dataset (GSE35452) from the Gene Expression Omnibus, National Center for Biotechnology Information identified the melanophilin (MLPH) gene as the most significant intracellular protein transport-related gene (GO:0006886) associated with a poor response to preoperative chemoradiation. An MLPH immunostain was performed on biopsy specimens from 172 rectal cancer patients receiving preoperative chemoradiation; samples were divided into high- and low-expression groups by H-scores. Subsequently, the correlations between MLPH expression and clinicopathologic features, tumor regression grade, disease-specific survival (DSS), local recurrence-free survival (LRFS), and metastasis-free survival (MeFS) were analyzed. MLPH expression was significantly associated with CEA level (p = 0.001), pre-treatment tumor status (p = 0.022), post-treatment tumor status (p < 0.001), post-treatment nodal status (p < 0.001), vascular invasion (p = 0.028), and tumor regression grade (p < 0.001). After uni- and multi-variable analysis of five-year survival, MLPH expression was still associated with lower DSS (hazard ratio (HR), 10.110; 95% confidence interval (CI), 2.178-46.920; p = 0.003) and MeFS (HR, 5.621; 95% CI, 1.762-17.931; p = 0.004). In conclusion, identifying MLPH expression could help to predict the response to chemoradiation and survival, and aid in personal therapeutic modification. |
| 關聯: | DIAGNOSTICS, v.11, n.11, pp.2132 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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