Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

doi:10.3390/ijms222111857

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Title:	Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
Authors:	Hung, Peir-Haur Hsu, Yung-Chien Chen, Tsung-Hsien Lin, Chun-Liang
Contributors:	Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth Chang Gung Mem Hosp, Dept Nephrol Chang Gung Mem Hosp, Kidney & Diabet Complicat Res Team KDCRT Chang Gung Univ, Coll Med, Sch Tradit Chinese Med Chang Gung Mem Hosp, Kidney Res Ctr Chang Gung Mem Hosp, Ctr Shockwave Med & Tissue Engn
Keywords:	diabetic kidney disease inflammation albuminuria fibrosis glomerulosclerosis
Date:	2021
Issue Date:	2023-11-11 11:44:37 (UTC+8)
Publisher:	MDPI
Abstract:	Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.
Relation:	INT J MOL SCI, v.22, n.21, pp.11857
Appears in Collections:	[Dept. of Life and Health Science] Other Projects

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