The Ethyl Acetate Subfraction of Polygonum cuspidatum Root Containing Emodin Affect EBV Gene Expression and Induce EBV-Positive Cells Apoptosis

doi:10.1248/bpb.b21-00508

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/34324

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题名:	The Ethyl Acetate Subfraction of Polygonum cuspidatum Root Containing Emodin Affect EBV Gene Expression and Induce EBV-Positive Cells Apoptosis
作者:	Yiu, Ching-Yi Chiu, Yu-Jhe Lin, Tsuey-Pin
贡献者:	Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chi Mei Med Ctr, Dept Otolaryngol
关键词:	Epstein-Barr virus latent membrane protein 1 Polygonum cuspidatum emodin
日期:	2021
上传时间:	2023-11-11 11:43:34 (UTC+8)
出版者:	PHARMACEUTICAL SOC JAPAN
摘要:	Epstein- Barr virus (EBV), a human herpesvirus, is several human lymphoid malignancies-associated. Our earlier study found the effect of Polygonum cuspidatum root on promoting EBV-positive apoptosis. Therefore, this study investigated the effects of the Polygonum cuspidatum ethyl acetate subfraction containing emodin on EBV gene expression and anti-EBV tumor cells. Resultantly, the the Polygonum cuspidatum ethyl acetate subfraction containing emodin ( F3a) promoted Raji cell death (50% cytotoxic concentration, CC50: 12.08 mu g/mL); the 12.5 mu g/mL F3a effect transcribed BRLF1 and BNLF1 and increased latent membrane protein 1 ( LMP1), which may reduce the intracellular phospho-extracellular signal-regulated kinase (ERK) and phospho-inhibitor of Nuclear factor kappa B a (I.Ba). Meanwhile, the Raji cells increased the intracellular reactive-oxygen species (ROS), activated the apoptosis-related proteins, cleaved caspase 3 and poly(ADP-ribose)polymerase (PARP), and increased the apoptosis percentage. Therefore, the Polygonum cuspidatum ethyl acetate subfraction containing emodin could be a therapeutic drug for EBV-related tumors.
關聯:	BIOL PHARM BULL, v.44, n.12, pp.1837-1842
显示于类别:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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