Complete and Durable Response to Nivolumab in Recurrent Poorly Differentiated Pancreatic Neuroendocrine Carcinoma with High Tumor Mutational Burden

doi:10.3390/curroncol28060388

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標題:	Complete and Durable Response to Nivolumab in Recurrent Poorly Differentiated Pancreatic Neuroendocrine Carcinoma with High Tumor Mutational Burden
作者:	Kang, Nai-Wen Tan, Kien-Thiam Li, Chien-Feng Kuo, Yu-Hsuan
貢獻者:	Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol ACT Genom Co Ltd Chi Mei Med Ctr, Dept Med Res Natl Inst Canc Res, Natl Hlth Res Inst Chia Nan Univ, Coll Pharm & Sci
關鍵字:	neuroendocrine carcinoma immunotherapy immune checkpoint inhibitor tumor mutational burden
日期:	2021
上傳時間:	2023-11-11 11:43:05 (UTC+8)
出版者:	MDPI
摘要:	Poorly differentiated pancreatic neuroendocrine carcinomas (NECs) are rare and aggressive malignancies with rapid disease progression and early widespread metastasis. Given histology similarity, they are commonly treated with platinum-based chemotherapy as small cell lung cancer (SCLC). However, no standard treatment has been established for recurrent or progressive disease. We present an Asian patient with recurrent poorly differentiated pancreatic NEC after curative surgery and adjuvant chemotherapy with cisplatin and etoposide. The tumor mutational burden (TMB) was high. The patient received chemotherapy combined with maintenance immunotherapy with nivolumab and achieved promising and durable response, suggesting TMB could be a biomarker to identify NEC patients for immune checkpoint inhibitor (ICI) treatment.
關聯:	CURR ONCOL, v.28, n.6, pp.4587-4596
顯示於類別:	[化妝品應用與管理系(所)] 期刊論文

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