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    標題: Longitudinal alterations of the cisternal segment of trigeminal nerve and brain pain-matrix regions in patients with trigeminal neuralgia before and after treatment
    作者: Chen, Tai-Yuan
    Ko, Ching-Chung
    Wu, Te-Chang
    Lin, Li-Ching
    Shih, Yun-Ju
    Hung, Yi-Chieh
    Chou, Ming-Chung
    貢獻者: Chi Mei Med Ctr, Dept Radiol
    Chang Jung Christian Univ, Grad Inst Med Sci
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chang Jung Christian Univ, Dept Med Sci Ind
    Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci
    Chi Mei Med Ctr, Dept Radiat Oncol
    Chi Mei Med Ctr, Dept Surg, Div Neurosurg
    Chia Nan Univ Pharm & Sci, Dept Recreat & Healthcare Management
    Kaohsiung Med Univ, Coll Hlth Sci, Dept Med Imaging & Radiol Sci
    Kaohsiung Med Univ Hosp, Dept Med Res
    Kaohsiung Med Univ, Ctr Big Data Res
    關鍵字: Trigeminal neuralgia
    Trigeminal nerve
    Pain-matrix regions
    RESOLVE DTI
    T2-SPACE VBM
    日期: 2021
    上傳時間: 2023-11-11 11:42:51 (UTC+8)
    出版者: BMC
    摘要: Background Trigeminal neuralgia (TN) is the most common type of chronic neuropathic facial pain, but the etiology and pathophysiological mechanisms after treatment are still not well understood. The purpose of this study was to investigate the longitudinal changes of the cisternal segment of the trigeminal nerve and brain pain-related regions in patients with TN before and after treatment using readout segmentation of long variable echo-train (RESOLVE) diffusion tensor imaging (DTI) and transverse relaxation (T2)-weighted sampling perfection with application-optimized contrast at different flip angle evolutions (T2-SPACE). Methods Twelve patients with TN and four healthy controls were enrolled in this study. All patients underwent assessment of the visual analog scale (VAS), and acquisition of RESOLVE DTI and T2-SPACE images before and at 1, 6, and 12 months after treatments. Regions-of-interest were placed on the bilateral anterior, middle, and posterior parts of the cisternal segment of the trigeminal nerve, the bilateral root entry zone (REZ), bilateral nuclear zone, and the center of pontocerebellar tracts, respectively. Voxel-based morphometry (VBM) analysis was conducted with T2-SPACE images, and gray matter volumes (GMV) were measured from brain pain-matrix regions. Results The results demonstrated that the VAS scores, the axial diffusivity of the middle part of the affected cisternal trigeminal nerve, the fractional anisotropy of the bilateral nuclear zones, and the mean diffusivity of the center of pontocerebellar tract significantly changed over time before and after treatment. The changes of GMV in the pain-matrix regions exhibited similar trends to the VAS before and after treatment. Conclusion We conclude that magnetic resonance imaging with RESOLVE DTI and VBM with T2-SPACE images were helpful in the understanding of the pathophysiological mechanisms in patients with TN before and after treatment.
    關聯: BMC NEUROSCI, v.22, n.1, pp.77
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