Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34314
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    標題: Molecular Mapping of Sebaceous Squalene by Ambient Mass Spectrometry
    作者: Cho, Yi-Tzu
    Su, Hung
    Wu, Ching-Ying
    Huang, Tiao-Lai
    Jeng, Jingyueh
    Huang, Min-Zong
    Wu, Deng-Chyang
    Shiea, Jentaie
    貢獻者: Natl Sun Yat Sen Univ, Dept Chem
    Kaohsiung Med Univ, Coll Med, Dept Dermatol
    Kaohsiung Municipal Tatung Hosp, Dept Dermatol
    Chang Gung Univ Sci & Technol, Dept Cosmet Sci
    Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Psychiat
    Chang Gung Univ, Coll Med
    Kaohsiung Chang Gung Mem Hosp, Dept Med Res, Genom & Prote Core Lab,
    Chia Nan Univ Pharm & Sci, Dept Med Chem
    Kaohsiung Med Univ Hosp, Dept Internal Med, Div Gastroenterol, Regenerat Med & Cell Therapy Res Ctr
    Kaohsiung Med Univ, Coll Med, Fac Med, Dept Med
    Yuh Ing Jr Coll Hlth Care & Management, Dept Cosmet Applicat & Management
    Kaohsiung Med Univ, Res Ctr Environm Med
    Kaohsiung Med Univ, Dept Med & Appl Chem
    日期: 2021
    上傳時間: 2023-11-11 11:42:49 (UTC+8)
    摘要: Squalene (SQ), a highly unsaturated sebaceous lipid, plays an important role in protecting human skin. To better understand the role of SQ in clinical medicine, an efficient analytical approach is needed to comprehensively study the distribution of SQ on different parts of the skin. In this study, sebaceous lipids were collected from different epidermal areas of a volunteer with sampling probes. Thermal desorption-electrospray ionization/mass spectrometry (TD-ESI/MS) was then used to characterize the lipid species on the probes, and each TD-ESI/MS analysis was completed within a few seconds without any sample pretreatment. The molecular mapping of epidermal squalene on whole-body skin was rendered by scaling the peak area of the extracted ion current (EIC) of SQ based on a temperature color gradient, where colors were assigned to the 1357 sampling locations on a 3D map of the volunteer. The image showed a higher SQ distribution on the face than any other area of the body, indicating the role of SQ in protecting facial skin. The results were in agreement with previous studies using SQ as a marker to explore sebaceous activity. The novelty and significance of this work are concluded as two points: (1) direct and rapid detection of all major dasses of sebaceous lipids, including the unsaturated hydrocarbons (SQ) and nonpolar lipids (e.g., cholesterol). The results are unique compared to other conventional and ambient ionization mass spectrometry methods and (2) this is the first study to analyze SQ distribution on the whole-body skin by a high-throughput approach.
    關聯: ANAL CHEM, v.93, n.49, pp.16608-16617
    显示于类别:[食藥產業暨檢測科技系(含五專)] 期刊論文


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