Different cutoffs of hypertension, risk of incident diabetes and progression of insulin resistance: A prospective cohort study

doi:10.1016/j.jfma.2021.02.022

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34313

Title:	Different cutoffs of hypertension, risk of incident diabetes and progression of insulin resistance: A prospective cohort study
Authors:	Lin, Chia-Hung Wei, Jung-Nan Fan, Kang-Chih Fang, Chi-Tai Wu, Wan-Chen Yang, Chung-Yi Lin, Mao-Shin Shih, Shyang-Rong Hua, Cyue-Huei Hsein, Yenh-Chen Lin, Jou-Wei Chuang, Lee-Ming Li, Hung-Yuan
Contributors:	Natl Taiwan Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Hsin Chu Branch Chia Nan Univ Pharm & Sci Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med Natl Taiwan Univ Hosp, Dept Internal Med Natl Taiwan Univ Hosp, Dept Internal Med, Div Endocrinol & Metab I Shou Univ, E Da Hosp, Dept Med Imaging Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol Natl Taiwan Univ, Coll Med, Dept Internal Med Natl Taiwan Univ Hosp, Ctr Antiaging & Hlth Consultat Natl Taiwan Univ Hosp, Yun Lin Branch, Div Clin Pathol, Touliu Natl Taiwan Univ Hosp, Yun Lin Branch, Dept Internal Med, Div Cardiol
Keywords:	Cutoffs Diabetes mellitus Hypertension Insulin resistance
Date:	2021
Issue Date:	2023-11-11 11:42:46 (UTC+8)
Publisher:	ELSEVIER TAIWAN
Abstract:	Background/Purpose: Hypertension is a risk factor of incident diabetes. In 2017, the ACC/AHA updated the definition of hypertension to above 130/80 mmHg, while the 2018 ESC/ESH guideline and the JNC7 criteria remained the cutoff of 140/90 mmHg. This study was aimed to investigate how different cutoffs of hypertension affect the association of hypertension to incident diabetes and the progression of insulin resistance. Methods: A total of 1177 subjects without diabetes at baseline were followed for 4.5 years. Diabetes was diagnosed by the results of oral glucose tolerance tests and hemoglobin A1c, or if anti-diabetic agents were used. Results: Hypertension by both criteria was associated with incident diabetes. Change of HOMA2-IR every 5 years (DHOMA2-IR/5 yr) was higher in subjects with hypertension than those without (adjusted p Z 0.044). Subjects with treated hypertension had the highest risk of diabetes (HR 2.98, p < 0.001) and DHOMA2-IR/5 yr, compared with subjects with normal blood pressure. However, the associations of hypertension, HR of incident diabetes and DHOMA2-IR/5 yr were attenuated by the 2017 ACC/AHA criteria, as compared with that by the JNC7 and 2018 ESC/ESH criteria. Conclusion: Hypertension by both criteria is associated with incident diabetes and accelerated progression of insulin resistance, and the associations are attenuated by the 2017 ACC/AHA criteria. Copyright 2021, Formosan Medical Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Relation:	J FORMOS MED ASSOC, v.121, n.1, pp.193-201
Appears in Collections:	[Dept. of Occupational Safety] Periodical Articles

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