Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34153
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18272/20499 (89%)
Visitors : 16230704      Online Users : 2016
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34153


    題名: First Glance of Molecular Profile of Atypical Cellular Angiofibroma/Cellular Angiofibroma with Sarcomatous Transformation by Next Generation Sequencing
    作者: Chien, Yi-Che Chang
    Mokanszki, Attila
    Huang, Hsuan-Ying
    Silva Jr, Raimundo Geronimo
    Chen, Chien-Chin
    Beke, Livia
    Monus, Aniko
    Mehes, Gabor
    貢獻者: Univ Debrecen, Clin Ctr, Dept Pathol
    Kaohsiung Chang Gung Mem Hosp, Dept Pathol
    Chang Gung Univ, Coll Med
    Univ Fed Piaui, Dept Pathol
    Ditmanson Med Fdn, Dept Pathol, Chia Yi Christian Hosp
    Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    關鍵詞: atypical angiofibroma
    angiofibroma with sarcomatous transformation
    p16
    p53
    next generation sequencing
    日期: 2020
    上傳時間: 2022-11-18 11:26:14 (UTC+8)
    出版者: Mdpi
    摘要: Cellular angiofibroma is a rare benign mesenchymal neoplasm most commonly occurring in the vulvovaginal region in women and the inguinoscrotal region in men with specific genetic deletion involved in the RB1 gene in chromosome 13q14 region. Atypical cellular angiofibroma and cellular angiofibroma with sarcomatous transformation are recently described variants showing worrisome morphological features and strong, diffuse p16 expression. Nevertheless, the molecular profile of these tumor entities is largely unknown. We carried out a next generation sequencing (NGS) study from six cases of atypical cellular angiofibroma and cellular angiofibroma with sarcomatous transformation. We were able to identify oncogenic TP53 gene mutations (33%) which may contribute to pathogenesis also resulting in p16 overexpression. In addition, RB1 gene alterations generally present were identified. Since it is a recently described and rare entity, the whole molecular signaling pathway is still largely obscured and the analysis of larger cohorts is needed to elucidate this issue.
    關聯: Diagnostics, v.10, n.1, pp.8
    顯示於類別:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    10.3390diagnostics10010035.pdf15377KbAdobe PDF423檢視/開啟
    index.html0KbHTML948檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋