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| 標題: | Extract Derived from Cedrus atlantica Acts as an Antitumor Agent on Hepatocellular Carcinoma Growth In Vitro and In Vivo |
| 作者: | Huang, Xiao-Fan
Chang, Kai-Fu
Lee, Shan-Chih
Sheu, Gwo-Tarng
Li, Chia-Yu
Weng, Jun-Cheng
Hsiao, Chih-Yen
Tsai, Nu-Man |
| 貢獻者: | Chung Shan Med Univ, Inst Med
Chung Shan Med Univ, Dept Med Lab & Biotechnol
Chung Shan Med Univ, Dept Med Imaging & Radiol Sci
Chung Shan Med Univ Hosp, Dept Med Imaging
Nanhua Univ, Dept Life & Death
Chang Gung Univ, Dept Med Imaging & Radiol Sci
Ditmanson Med Fdn Chia Yi Christian Hosp, Div Nephrol, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Chung Shan Med Univ Hosp, Clin Lab |
| 關鍵字: | hepatocellular carcinoma (HCC)
Cedrus atlantica extract (CAt extract)
cell cycle
apoptosis |
| 日期: | 2020 |
| 上傳時間: | 2022-11-18 11:26:02 (UTC+8) |
| 出版者: | Mdpi |
| 摘要: | Cedrus atlantica is widely used in herbal medicine. However, the anti-cancer activity of C. atlantica extract (CAt extract) has not been clarified in hepatocellular carcinoma. In the study, we elucidated the anti-hepatoma capacity of CAt extract on HCC in vitro and in vivo. To explore the anti-hepatoma mechanisms of the CAt extract in vitro, HCC and normal cells were treated with the CAt extract, which showed marked inhibitory effects on HCC cells in a dose-dependent manner; in contrast, the CAt extract treatment was less cytotoxic to normal cells. In addition, our results indicate that the CAt extract induced apoptosis via caspase-dependent and independent apoptosis pathways. Furthermore, the CAt extract inhibited HCC tumor cell growth by restraining cell cycle progression, and it reduced the signaling of the AKT, ERK1/2, and p38 pathways. In the xenograft model, the CAt extract suppressed HCC tumor cell growth and prolonged lifespan by inhibiting PCNA protein expression, repressing part of the VEGF-induced autocrine pathway, and triggering strong expression of cleaved caspase-3, which contributed to cell apoptosis. Moreover, the CAt extract did not induce any obvious changes in pathological morphology or body weight, suggesting it had no toxicity. CAt extract exerted anti-tumor effects on HCC in vitro and in vivo. Thus, CAt extract could be used as a potential anti-cancer therapeutic agent against HCC. |
| 關聯: | Molecules, v.25, n.20, pp.16 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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