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| 標題: | Expression and prognostic utility of SSX2IP in patients with nasopharyngeal carcinoma |
| 作者: | Chang, Shih-Lun
Lee, Sung-Wei
Yang, Sheau-Fang
Chien, Chu-Chun
Chan, Ti-Chun
Chen, Tzu-Ju
Yang, Ching-Chieh
Li, Chien-Feng
Wei, Yu-Ching |
| 貢獻者: | Chi Mei Med Ctr, Dept Otolaryngol
Chung Hwa Univ Med Technol, Dept Optometry
Chi Mei Med Ctr, Dept Radiat Oncol
Kaohsiung Med Univ Hosp, Dept Pathol
Kaohsiung Med Univ, Coll Med, Sch Med, Dept Pathol
Kaohsiung Municipal Tatung Hosp, Dept Pathol
Chi Mei Med Ctr, Dept Med Res
Chi Mei Med Ctr, Dept Pathol
Natl Sun Yat Sen Univ, Inst Biomed Sci
Chi Mei Med Ctr, Dept Radiat Oncol
Chia Nan Univ Pharm & Sci, Dept Pharm
Natl Hlth Res Inst, Natl Inst Canc Res
Southern Taiwan Univ Sci & Technol, Dept Biotechnol |
| 關鍵字: | Prognostic markers
SSX2IP
prognosis
nasopharyngeal carcinoma |
| 日期: | 2020 |
| 上傳時間: | 2022-11-18 11:26:00 (UTC+8) |
| 出版者: | Wiley |
| 摘要: | Cell adhesion affects carcinogenesis, tumor progression, and metastasis. We datamined a published transcriptome () of nasopharyngeal carcinoma (NPC) and identified SSX2IP as a significantly upregulated gene in NPC carcinogenesis among genes associated with cell adhesion (GO:0007155). Consequently, we assessed SSX2IP protein expression and its prognostic significance in 124 patients with NPC using immunohistochemistry and the H-score method. The status of SSX2IP immunoexpression correlated with clinical and pathological characteristics, as well as oncological outcomes. High levels of SSX2IP expression were significantly associated with more advanced primary tumor and TNM stages. Kaplan-Meier and log-rank analyses revealed that high levels of SSX2IP expression, and advanced tumor stage and lymph node metastasis were significantly associated with lower rates of local recurrence-free survival (LRFS), distant metastasis-free survival (DMeFS), and disease-specific (DSS) survival. Multivariate analysis showed that high levels of SSX2IP expression significantly predicted DSS (hazard ratio [HR], 4.290; 95% confidence interval [CI], 2.271-8.102; p < 0.001), DMeFS (HR, 4.159' 95% CI, 2.072-8.345; p < 0.001), and LRFS (HR, 3.007' 95% CI,: 1.418-6.378; p = 0.004). We associated high levels of SSX2IP immunoexpression with aggressive pathological features and worse oncological outcomes, suggesting its potential therapeutic value for patients with NPC. |
| 關聯: | Apmis, v.128, n.4, pp.11 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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