Effects of Hyperbaric Oxygen Therapy on Acute Myocardial Infarction Following Carbon Monoxide Poisoning

doi:10.1007/s12012-019-09552-7

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Title:	Effects of Hyperbaric Oxygen Therapy on Acute Myocardial Infarction Following Carbon Monoxide Poisoning
Authors:	Huang, Chien-Cheng Ho, Chung-Han Chen, Yi-Chen Hsu, Chien-Chin Lin, Hung-Jung Wang, Jhi-Joung Su, Shih-Bin Guo, How-Ran
Contributors:	Chi Mei Med Ctr, Dept Emergency Med Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth Southern Taiwan Univ Sci & Technol, Dept Senior Serv Chi Mei Med Ctr, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Southern Taiwan Univ Sci & Technol, Dept Biotechnol Taipei Med Univ, Dept Emergency Med Chi Mei Med Ctr, Dept Occupat Med Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management Chi Mei Med Ctr, Dept Med Res Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med
Keywords:	Carbon monoxide Hyperbaric oxygen therapy Myocardial infarction Poisoning
Date:	2020
Issue Date:	2022-11-18 11:25:43 (UTC+8)
Publisher:	Humana Press Inc
Abstract:	Carbon monoxide poisoning (COP) may increase the risk of myocardial infarction. We conducted a study to investigate the effects of hyperbaric oxygen therapy (HBOT) on the risk. We used the Nationwide Poisoning Database in Taiwan to identify COP patients diagnosed between 1999 and 2012. We compared the risk for myocardial infarction between patients with and without HBOT by following up through 2013 and identified the independent predictors of myocardial infarction. The risk of myocardial infarction in the 7278 patients with HBOT was lower than in the 18,459 patients without HBOT, but this difference did not reach statistical significance [adjusted hazard ratio (AHR): 0.69; 95% confidence interval (CI) 0.45-1.07]. Stratified analyses showed that the reductions in the risk associated with HBOT for myocardial infarction reached statistical significance in male patients (AHR: 0.45; 95% CI 0.24-0.83) and during the first 2 weeks of follow-up (AHR: 0.22; 95% CI 0.05-0.96). In patients without HBOT, independent predictors of myocardial infarction were old age, male sex, and the underlying comorbidities of hypertension, diabetes, coronary artery disease, and congestive heart failure. In patients with HBOT, however, old age, male sex, and the underlying comorbidities of diabetes, coronary artery disease, and congestive heart failure were not independent predictors. HBOT was associated with a reduced risk of myocardial infarction in male patients and within 2 weeks following COP. These results may provide important reference for using HBOT in treating COP.
Relation:	Cardiovascular Toxicology, v.20, n.3, pp.10
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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