資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/34134
|
| 標題: | Does radiotherapy increase the risk of colorectal cancer among prostate cancer patients? A large population-based study |
| 作者: | Ho, Chung-Han
Cheng, Kuo-Chen
Chao, Chien-Ming
Lai, Chih-Cheng
Chiang, Shyh-Ren
Chen, Chin-Ming
Liao, Kuang-Ming
Wang, Jhi-Joung
Lee, Po-Huang
Hung, Chao-Ming
Tai, Chi-Ming
Chiu, Chong-Chi |
| 貢獻者: | Chi Mei Med Ctr, Dept Med Res
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Taipei Med Univ, Wan Fang Hosp, Canc Ctr
Chi Mei Med Ctr, Dept Internal Med
Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm
Chi Mei Med Ctr, Dept Intens Care Med
Chi Mei Med Ctr, Dept Intens Care Med
Min Hwei Coll Hlth Care Management, Dept Dent Lab Technol
Kaohsiung Vet Gen Hosp, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Gen Educ
Chi Mei Med Ctr, Dept Internal Med
Southern Taiwan Univ Sci & Technol, AI Biomed Ctr
I Shou Univ, Dept Surg, E Da Hosp
I Shou Univ, Dept Gen Surg, E Da Canc Hosp
I Shou Univ, Dept Internal Med, E Da Hosp |
| 關鍵字: | secondary colorectal cancer
prostate cancer
radiotherapy
radical prostatectomy
large population-based study |
| 日期: | 2020 |
| 上傳時間: | 2022-11-18 11:25:24 (UTC+8) |
| 出版者: | Ivyspring Int Publ |
| 摘要: | Objective: The survival of prostate cancer (PC) patients after radiotherapy (RT) has improved over time, but it raises the debate of increased risk of secondary colorectal cancer (SCRC). This study aimed to assess whether RT for PC treatment increases the risk of SCRC in comparison with radical prostatectomy (RP). Methods: A population-based cohort of PC patients treated only with RT or only with RP between January 2007 and December 2015 was identified from the Taiwan Cancer Registry. The incidence rate of SCRC development was estimated using Cox regression model. Results: In this study, total 8,797 PC patients treated with either RT (n = 3,219) or RP (n =5,578). Patients subjected to RT were elder (higher percentage of 70 >= years, p < 0.0001) and more advanced clinically (stage III: 22.90% vs. 11.87%; stage IV: 22.15% vs. 13.80%, p < 0.0001), compared to those subjected to RP. More patients subjected to RT had a much higher percentage of autoimmune disease (22.34% vs. 18.75%, p < 0.0001) and osteoarthritis and allied disorders (16.31% vs. 12.98%, p < 0.0001). Besides, RT patients had a higher percentage of underlying Crohn's disease (0.25% vs. 0.05%, p = 0.0230). Although almost all selected factors were not statistically significant, they presented the positive risk of SCRC for those under RP compared with those among RT. Besides, for PC patients in clinical stage I and II, patients with RP may have borderline significantly protective effects of SCRC compared with those under RT (stage I, HR: 0.14; 95% C.I.:0.01-1.39; p = 0.0929; stage II, HR: 1.92; 95% C.I.:0.93-3.95; p = 0.0775). Kaplan-Meier curves for a 3-year-period, which demonstrated no statistical difference in the risk of SCRC free between PC patients undergoing RT and RP (p = 0.9766). Conclusion: Whether or not pelvic RT for PC is associated with an increased risk for SCRC on a population-based level remains a matter of considerable debate. From a clinical perspective, these PC survivors should be counseled accordingly and received continued cancer surveillance with regular colonoscopy follow-up. |
| 關聯: | Journal of Cancer, v.11, n.21, pp.9 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| 10.7150_jca.44726.pdf | | 800Kb | Adobe PDF | 170 | 檢視/開啟 | | index.html | | 0Kb | HTML | 522 | 檢視/開啟 |
|
在CNU IR中所有的資料項目都受到原著作權保護.
|
