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| 標題: | D-methionine improves cisplatin-induced anorexia and dyspepsia syndrome by attenuating intestinal tryptophan hydroxylase 1 activity and increasing plasma leptin concentration |
| 作者: | Wong, Yi-Sin
Lin, Meei-Yn
Liu, Pei-Fen
Ko, Jiunn-Liang
Huang, Guan-Ting
Tu, Dom-Gene
Ou, Chu-Chyn |
| 貢獻者: | Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Family Med
Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
Natl Chung Hsing Univ, Dept Food Sci & Biotechnol
Chung Shan Med Univ Hosp, Dept Med Oncol & Chest Med
Chung Shan Med Univ, Inst Med
Chung Shan Med Univ Hosp, Dept Nutr
Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Nucl Med
Natl Chung Cheng Univ, Dept Biomed Sci
Chung Shan Med Univ, Sch Nutr |
| 關鍵字: | 5-HT3 receptor
anorexia
cisplatin
D-methionine
dyspepsia syndrome |
| 日期: | 2020 |
| 上傳時間: | 2022-11-18 11:25:21 (UTC+8) |
| 出版者: | Wiley |
| 摘要: | Background Cisplatin is a widely used antineoplastic drug. However, cisplatin-induced dyspepsia syndromes, including delayed gastric emptying, gastric distension, early satiety, nausea, and vomiting, often force patients to take doses lower than those prescribed or even refuse treatment. D-methionine has an appetite-enhancing effect and alleviates weight loss during cisplatin treatment. Methods This work established a model of anorexia and dyspepsia symptoms with intraperitoneal injection of cisplatin (5 mg/kg) once a week for three cycles. Presupplementation with or without D-methionine (300 mg/kg) was performed. Orexigenic and anorexigenic hormones (ghrelin, leptin, and glucagon-like peptide-1), tryptophan hydroxylase 1 (TPH1), 5-hydroxytryptamine receptors (5-HT2C and 5-HT3), and hypothalamic feeding-related peptides were measured by immunohistochemistry staining, enzyme-linked immunosorbent assay, and real-time PCR assay. Key results Cisplatin administration caused marked decrease in appetite and body weight, promoted adipose and fat tissue atrophy, and delayed gastric emptying and gastric distension, and D-methionine preadministration prior to cisplatin administration significantly ameliorated these side effects. Besides, cisplatin induced an evident increase in serum ghrelin level, TPH1 activity, and 5-HT3 receptor expression in the intestine and decreased plasma leptin levels and gastric ghrelin mRNA gene expression levels. D-methionine supplementation recovered these changes. The expression of orexigenic neuropeptide Y/agouti-related peptide and anorexigenic cocaine- and amphetamine-regulated transcript proopiomelanocortin neurons were altered by D-methionine supplementation in cisplatin-induced anorexia rats. Conclusions and inferences D-methionine supplementation prevents cisplatin-induced anorexia and dyspepsia syndrome possibly by attenuating intestinal tryptophan hydroxylase 1 activity and increasing plasma leptin concentration. Therefore, D-methionine can be used as an adjuvant therapy for treating cisplatin-induced adverse effects. |
| 關聯: | Neurogastroenterology and Motility, v.32, n.6, pp.13 |
| 顯示於類別: | [ 食品科技系 ] 期刊論文
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