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| 標題: | Cytoplasmic, but not nuclear Nrf2 expression, is associated with inferior survival and relapse rate and response to platinum-based chemotherapy in non-small cell lung cancer |
| 作者: | Chen, Ming-Jenn
Lin, Po-Lin
Wang, Lee
Cheng, Ya-Min
Chen, Chih-Yi
Lee, Huei |
| 貢獻者: | Chi Mei Med Ctr, Dept Surg
Chia Nan Univ Pharm & Sci, Dept Sports Management, Coll Leisure & Recreat Management
Taipei Med Univ, Grad Inst Canc Biol & Drug Discovery
Chung Shan Med Univ, Dept Publ Hlth
Natl Cheng Kung Univ, Dept Obstet & Gynecol, Coll Med
Chung Shan Med Univ Hosp, Dept Surg |
| 關鍵字: | NSCLC
chemotherapeutic response
cytoplasmic Nrf2
prognosis |
| 日期: | 2020 |
| 上傳時間: | 2022-11-18 11:25:00 (UTC+8) |
| 出版者: | Wiley |
| 摘要: | Background Several studies have previously indicated that nuclear factor erythroid 2-related factor 2 (Nrf2) expression may promote tumor progression when the Keap1/Nrf2 pathway is activated, but few reports have demonstrated the role of cytoplasmic Nrf2 on tumorigenesis. Methods Immunohistochemistry was conducted to evaluate Nrf2 expression in 167 tumors from surgically-resected patients with non-small cell lung cancer (NSCLC). Univariate and multivariate analyses were performed to examine the association of Nrf2 expression with patients' prognosis. This study was conducted to examine the association of Nrf2 expression with tumor response to cisplatin-based chemotherapy. Results Among these tumors, 56 and 32 of 167 tumors expressed Nrf2 in the cytoplasm (34% for C+/N-) and in the cytoplasm/nucleus (19% for C+/N+), but not in the nucleus of tumor cells. Nrf2 was negatively expressed in the remainder of the tumor samples (C-/N-, 79 of 167, 47%). Univariate analysis indicated that patients with Nrf2 positive tumors (C+/N- plus C+/N+) had worse overall survival (OS), but not relapse-free survival (RFS) than with Nrf2 negative tumors (C-/N-). However, patients with C+/N- tumors possessed worse OS and RFS than those with Nrf2 negative tumors (C-/N-). Multivariate analysis further confirmed the prognostic significance of patients with Nrf2 positive and C+/N- tumors on OS and RFS, but not on RFS for patients with Nrf2 positive tumors. Patients with Nrf2 positive and C+/N- tumors were determined to more frequently have an unfavorable response to cisplatin-based chemotherapy than those with Nrf2 negative tumors. Conclusions Cytoplasmic Nrf2 expression might potentially be used to predict poor prognosis and unfavorable response to cisplatin-based chemotherapy in patients with NSCLC. |
| 關聯: | Thoracic Cancer, v.11, n.7, pp.7 |
| 顯示於類別: | [運動管理系] 期刊論文
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