Cytologic diagnosis of medullary thyroid carcinoma in theAsia-Pacificregion

doi:10.1002/dc.24586

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/34125

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Title:	Cytologic diagnosis of medullary thyroid carcinoma in theAsia-Pacificregion
Authors:	Liu, Chih-Yi Bychkov, Andrey Agarwal, Shipra Zhu, Yun Hang, Jen-Fan Lai, Chiung-Ru Na, Hee Young Li, Weiwei Liu, Zhiyan Jain, Deepali Suzuki, Ayana Hirokawa, Mitsuyoshi Chia, Noel Nga, Min En Jitpasutham, Tikamporn Keelawat, Somboon Park, So Yeon Satoh, Shinya Chen, Chien-Chin Gunawardena, Dilini Kumarasinghe, Priyanthi Jung, Chan Kwon Kakudo, Kennichi
Contributors:	Sijhih Cathay Gen Hosp, Div Pathol Kameda Med Ctr, Dept Pathol, Kamogawa Nagasaki Univ, Dept Pathol, Grad Sch Biomed Sci, Nagasaki All India Inst Med Sci, Dept Pathol Jiangsu Inst Nucl Med, Dept Pathol Taipei Vet Gen Hosp, Dept Pathol & Lab Med Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Pathol, Seongnam Shandong Univ, Dept Pathol, Sch Basic Med Sci Kuma Hosp, Dept Diagnost Pathol & Cytol Natl Univ Singapore Hosp, Dept Pathol Chulalongkorn Univ, Dept Pathol, Fac Med Yamashita Thyroid & Parathyroid Clin, Dept Endocrine Surg, Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Univ Western Australia, Sch Pathol & Lab Med Catholic Univ Korea, Dept Hosp Pathol, Coll Med Izumi City Gen Hosp, Dept Pathol & Thyroid Dis Ctr
Keywords:	Asia-Pacific fine needle aspiration cytology medullary thyroid carcinoma sensitivity and specificity thyroid
Date:	2021
Issue Date:	2022-11-18 11:24:57 (UTC+8)
Publisher:	Wiley
Abstract:	Background The accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to the rarity of tumor and variable cytologic appearance. The Asian experience with diagnosing MTC by fine-needle aspiration (FNA) was scarcely reported. Methods Cases of MTC with available FNA slides were enrolled from 13 hospitals representing 8 Asia-Pacific countries. Clinicopathological information, including sample preparation technique, staining method, original cytologic diagnosis and review diagnosis were collected. Results Of a total of 145 MTC cases retrospectively recruited, 99 (68.3%) were initially interpreted as MTC/suspicious for MTC (S-MTC). The distribution of original FNA diagnostic categories was not associated with the staining method or sample preparation technique. The staining methods used were Papanicolaou, hematoxylin-eosin and Romanowsky stains. Liquid-based cytology (LBC) was used only in three countries. After reviewing all cases, the diagnostic rate of MTC/S-MTC increased to 91.7% (133/145). Cases with initially unrecognized MTC had either marked pleomorphism or cytology mimicking papillary carcinoma or follicular neoplasm. Although LBC provided certain benefits, there was no significant difference in diagnostic accuracy between conventional smear and LBC. Immunocytochemistry was available in 38 cases (26.2%), all of which were correctly recognized as MTC. Conclusion Our report summarizes how MTC is handled in contemporary Asian thyroid FNA practice. Although the detection rate of MTC by cytology alone is less satisfactory, integration with ancillary tests could achieve an excellent performance. The recognition of constitutive cytomorphologic features is needed for each cytopreparatory method, which may result in a lower threshold to initiate further workup for MTC.
Relation:	Diagnostic Cytopathology, v.49, n.1, pp.10
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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