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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34118


    標題: Correlation of internal carotid artery diameter and carotid flow with asymmetry of the circle of Willis
    作者: Wu, Te-Chang
    Chen, Tai-Yuan
    Ko, Ching-Chung
    Chen, Jeon-Hor
    Lin, Ching-Po
    貢獻者: Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci
    Chang Jung Christian Univ, Dept Med Sci Ind
    Chi Mei Med Ctr, Dept Med Imaging
    Chang Jung Christian Univ, Grad Inst Med Sci
    Chia Nan Univ Pharm & Sci, Ctr Gen Educ
    I Shou Univ, E DA Hosp, E DA Canc Hosp, Dept Radiol
    Univ Calif Irvine, Sch Med, Ctr Funct Onco Imaging Radiol Sci, Irvine
    Natl Yang Ming Univ, Sch Life Sci, Inst Neurosci
    關鍵字: Cerebral blood flow
    Carotid artery
    MR angiography
    Cerebral hemodynamics
    Neuroanatomy
    Ultrasound
    日期: 2020
    上傳時間: 2022-11-18 11:24:37 (UTC+8)
    出版者: Bmc
    摘要: Background The purpose of this study was to clarify the effect of asymmetric COW variants on carotid flow changes, and proposed an easy estimate of the representative carotid flow volume for accurate numerical simulation. Methods A total of 210 healthy adults receiving magnetic resonance angiography and carotid duplex sonography were included. Three anterior cerebral artery asymmetry (AA) groups were defined based on the diameter ratio difference (DRD) of bilateral A1 segments: AA1 group, one-side A1 aplasia; AA2, A1 DRD >= 50%; AA3, A1 DRD between 10 and 50%. Similarly, 3 posterior communicating artery (PcomA) asymmetry (PA) groups were defined: PA1 group, one fetal-origin posterior cerebral artery and absent contralateral PcomA; PA2, PcomA DRD >= 50%; PA3, PcomA DRD between 10 and 50%. Results With A1 asymmetry, the ICA diameter of the dominant A1 is significantly greater than the contralateral side. Significant differences of bilateral ICA flow were present in the AA1 and AA2 groups (mean flow difference 42.9 and 30.7%, respectively). Significant bilateral ICA diameter and flow differences were only found in the PA1 group. Linear regression analysis of ICA diameter and flow found a moderately positive correlation between ICA diameter and flow in all AA groups, with a 1 mm increment in vessel diameter corresponding to a 62.6 ml increment of flow volume. The product of bilateral ICA diameter and flow volume difference (ICA-PDF) could be a potential discriminator with a cutoff of 4.31 to predict A1 asymmetry >= 50% with a sensitivity of 0.81 and specificity of 0.76. Conclusions The study verifies that A1 asymmetry causes unequal bilateral carotid inflow, and consequently different bilateral ICA diameters. Adjustment of the inflow boundary conditions according to the COW variants would be necessary to improve the accuracy of numerical simulation.
    關聯: Bmc Neurology, v.20, n.1, pp.9
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