Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34110
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    Title: Collagen formula with Djulis for improvement of skin hydration, brightness, texture, crow's feet, and collagen content: A double-blind, randomized, placebo-controlled trial
    Authors: Lin, Ping
    Alexander, Ruth Audy
    Liang, Chia-Hua
    Liu, Cheng
    Lin, Yung-Hao
    Lin, Yung-Hsiang
    Chan, Leong-Perng
    Kuan, Chen-Meng
    Contributors: TCI CO Ltd, Res & Design Ctr
    Kalbe Farma, Kalbe Nutr Res Ctr, Jakarta
    Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
    Shu Zen Jr Coll Med & Management, Dept Dent Technol,
    TCI CO Ltd, Global Business Ctr
    Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Otorhinolaryngol Head & Neck Surg
    Kaohsiung Med Univ, Univ Hosp, Coll Med, Fac Med
    Keywords: Chenopodium formosanum Koidz
    hydrolyzed fish collagen
    skin aging
    Date: 2021
    Issue Date: 2022-11-18 11:24:19 (UTC+8)
    Publisher: Wiley
    Abstract: Background The efficacy of Djulis for skin care is currently based on cellular or animal models, and the clinical aspect is not in place. Aim This clinical study is to investigate the synergistic effect of fish collagen and Djulis (Chenopodium formosanumKoidz.) for improvement of skin parameters. We used the combination of hydrolyzed collagen and Djulis to develop a new functional formula for skin improvement. Patients/Methods Fifty volunteers were randomly allocated (in a 1:1 ratio) to the placebo or collagen drink group. Volunteers were required to consume a 50 mL of a collagen drink or placebo drink daily for 8 weeks. For measurements, the indexes of skin conditions were measured at the baseline and 4 and 8 weeks. Results The improvements of skin hydration, brightness, crow's feet, texture, wrinkles, pores, spots, and collagen content after 8 weeks in collagen group were 17.8%, 5.4%, 14.9%, 9.9%, 29.3%, 10.4%, 9.9%, and 22.3%, respectively. Noticeably, over 68% of subjects got improved for their skin parameters after 8-week intake of collagen drink. The improvement levels indicated competitive skin improvement effects in comparison with previous studies. Conclusion This clinical study demonstrates the synergistic effect of fish collagen and Djulis (the main components) for the substantial improvements in hydration, brightness, crow's feet, texture, wrinkles, pores, surface spots, and collagen content in skin. The collagen drink comprehensively improved skin parameters for most subjects after 4-week intake and manifested competitive efficiency in comparison with other similar studies. We convince that the collagen drink may delay skin aging process and improve skin aging parameters.
    Relation: Journal of Cosmetic Dermatology, v.20, n.1, pp.7
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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