Clinical burden of autosomal dominant polycystic kidney disease

doi:10.18632/aging.102858

CNU IR > College of Smart Living > Dept. of Life and Health Science > Periodical Articles > Item 310902800/34107

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Title:	Clinical burden of autosomal dominant polycystic kidney disease
Authors:	Hung, Peir-Haur Lin, Chien-Hung Hung, Kuan-Yu Muo, Chih-Hsin Chung, Mu-Chi Chang, Chao-Hsiang Chung, Chi-Jung
Contributors:	Ditmanson Med Fdn, Dept Internal Med, Chiayi Christian Hosp Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth Taipei Vet Gen Hosp, Dept Pediat, Div Pediat Immunol & Nephrol Natl Yang Ming Univ, Inst Clin Med Taipei City Hosp, Dept Pediat, Zhongxing Branch Fu Jen Catholic Univ, Coll Sci & Engn Natl Taiwan Univ Hosp, Dept Internal Med China Med Univ Hosp, Management Off Hlth Data Taichung Vet Gen Hosp, Dept Med, Div Nephrol China Med Univ Hosp, Dept Urol China Med Univ Hosp, Dept Med Res China Med Univ, Dept Publ Hlth
Keywords:	autosomal dominant polycystic kidney disease hemorrhagic stroke end-stage renal disease all-cause mortality time-dependent Cox proportional hazard regression
Date:	2020
Issue Date:	2022-11-18 11:24:12 (UTC+8)
Publisher:	Impact Journals Llc
Abstract:	There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individually selected patients with and without ADPKD from inpatient data files as well as from the catastrophic illness registry in Taiwan based on 1:5 frequency matching for sex, age, and index year. The hazard ratios (HR) of all-cause mortality, ischemic stroke, hemorrhagic stroke and end-stage renal disease (ESRD) in ADPKD inpatients were elevated as compared to the controls. Similarly, ADPKD patients from the catastrophic illness registry had an increased risk of hemorrhagic stroke and ESRD. Allopurinol users also had an increased risk of all-cause mortality. The HR for developing ESRD after medication exposure was 0.47-fold for statin and 1.93-fold for pentoxifylline. These results reveal that patients with ADPKD (either inpatient or from the catastrophic illness registry) are at elevated risk for hemorrhagic stroke and ESRD, and suggest that allopurinol and pentoxifylline should not be prescribed to ADPKD patients due to possible adverse effects.
Relation:	Aging-Us, v.12, n.4, pp.12
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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