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https://ir.cnu.edu.tw/handle/310902800/34107
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| Title: | Clinical burden of autosomal dominant polycystic kidney disease |
| Authors: | Hung, Peir-Haur
Lin, Chien-Hung
Hung, Kuan-Yu
Muo, Chih-Hsin
Chung, Mu-Chi
Chang, Chao-Hsiang
Chung, Chi-Jung |
| Contributors: | Ditmanson Med Fdn, Dept Internal Med, Chiayi Christian Hosp
Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
Taipei Vet Gen Hosp, Dept Pediat, Div Pediat Immunol & Nephrol
Natl Yang Ming Univ, Inst Clin Med
Taipei City Hosp, Dept Pediat, Zhongxing Branch
Fu Jen Catholic Univ, Coll Sci & Engn
Natl Taiwan Univ Hosp, Dept Internal Med
China Med Univ Hosp, Management Off Hlth Data
Taichung Vet Gen Hosp, Dept Med, Div Nephrol
China Med Univ Hosp, Dept Urol
China Med Univ Hosp, Dept Med Res
China Med Univ, Dept Publ Hlth |
| Keywords: | autosomal dominant polycystic kidney disease
hemorrhagic stroke
end-stage renal disease
all-cause mortality
time-dependent Cox proportional hazard regression |
| Date: | 2020 |
| Issue Date: | 2022-11-18 11:24:12 (UTC+8) |
| Publisher: | Impact Journals Llc |
| Abstract: | There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individually selected patients with and without ADPKD from inpatient data files as well as from the catastrophic illness registry in Taiwan based on 1:5 frequency matching for sex, age, and index year. The hazard ratios (HR) of all-cause mortality, ischemic stroke, hemorrhagic stroke and end-stage renal disease (ESRD) in ADPKD inpatients were elevated as compared to the controls. Similarly, ADPKD patients from the catastrophic illness registry had an increased risk of hemorrhagic stroke and ESRD. Allopurinol users also had an increased risk of all-cause mortality. The HR for developing ESRD after medication exposure was 0.47-fold for statin and 1.93-fold for pentoxifylline. These results reveal that patients with ADPKD (either inpatient or from the catastrophic illness registry) are at elevated risk for hemorrhagic stroke and ESRD, and suggest that allopurinol and pentoxifylline should not be prescribed to ADPKD patients due to possible adverse effects. |
| Relation: | Aging-Us, v.12, n.4, pp.12 |
| Appears in Collections: | [Dept. of Life and Health Science] Periodical Articles
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