Chloroquine for prolonged skin analgesia in rats

doi:10.1016/j.neulet.2020.135233

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Title:	Chloroquine for prolonged skin analgesia in rats
Authors:	Chang, Ying-Jen Liu, Kuo-Sheng Wang, Jhi-Joung Hung, Ching-Hsia Chen, Yu-Wen
Contributors:	Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Pharm Chi Mei Med Ctr, Dept Med Res Southern Taiwan Univ Sci & Technol, Allied AI Biomed Ctr Natl Cheng Kung Univ, Coll Med, Dept Phys Therapy Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci China Med Univ, Coll Hlth Care, Dept Phys Therapy
Keywords:	Chloroquine Epinephrine Bupivacaine Subcutaneous injection Infiltrative cutaneous analgesia
Date:	2020
Issue Date:	2022-11-18 11:23:57 (UTC+8)
Publisher:	Elsevier Ireland Ltd
Abstract:	The purpose of this study was to investigate the ability of chloroquine and chloroquine in combination with vasoconstrictor epinephrine to act as a local anesthetic in skin analgesia. After subcutaneous injection of drugs in rats, the inhibition of the cutaneous trunci muscle reflex (CTMR) is designed for evaluation of the cutaneous analgesic effect. The analgesic effect of chloroquine was compared with that of bupivacaine or coadministration of chloroquine and epinephrine. Chloroquine produced exactly the same local anesthesia as bupivacaine did in a dose-dependent manner. On the ED50 (50 % effective dose) basis, the analgesic potency was chloroquine (4.81 [4.45-5.20] mu mol) < bupivacaine (0.46 [0.40-0.52] mu mol) (p < 0.01). At every equipotent dose tested (ED25, ED50 and ED75), chloroquine had a longer duration of cutaneous analgesia than bupivacaine (p < 0.01). Epinephrine enhanced the potency and duration of chloroquine-induced cutaneous analgesia. We found that chloroquine and bupivacaine elicit dose-dependent cutaneous analgesia. Chloroquine is not as potent as bupivacaine, but acts as an infiltrative anesthetic for a longer duration of time and is more potent and effective when used in combination with epinephrine.
Relation:	Neuroscience Letters, v.735, pp.5
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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