Autoimmune Connective Tissue Disease Following Carbon Monoxide Poisoning: A Nationwide Population-Based Cohort Study

doi:10.2147/CLEP.S266396

CNU IR > College of Smart Living > Dept. of Hospital and Health (including master's program) > Periodical Articles > Item 310902800/34086

請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34086

題名:	Autoimmune Connective Tissue Disease Following Carbon Monoxide Poisoning: A Nationwide Population-Based Cohort Study
作者:	Huang, Chien-Cheng Ho, Chung-Han Chen, Yi-Chen Hsu, Chien-Chin Lin, Hung-Jung Wang, Jhi-Joung Guo, How-Ran
貢獻者:	Chi Mei Med Ctr, Dept Emergency Med Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth Southern Taiwan Univ Sci & Technol, Dept Senior Serv Chi Mei Med Ctr, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Southern Taiwan Univ Sci & Technol, Dept Biotechnol Taipei Med Univ, Dept Emergency Med Southern Taiwan Univ Sci & Technol, Allied AI Biomed Ctr Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med Natl Cheng Kung Univ Hosp, Occupat Safety Hlth & Med Res Ctr
關鍵詞:	autoimmune carbon monoxide poisoning connective tissue disease hypoxia inflammation oxidative stress
日期:	2020
上傳時間:	2022-11-18 11:23:19 (UTC+8)
出版者:	Dove Medical Press Ltd
摘要:	Background: In addition to hypoxia, oxidative stress and inflammation due to carbon monoxide (CO) poisoning cause adverse health effects. These mechanisms are related to the occurrence of autoimmune connective tissue disease, but studies on the association between CO poisoning and autoimmune connective tissue disease are limited. We conducted a study to evaluate the occurrence of autoimmune connective tissue disease following CO poisoning. Methods: We identified participants with CO poisoning diagnosed between 1999 and 2012 from the Nationwide Poisoning Database and selected participants without CO poisoning from the Taiwan National Health Insurance Research Database with matching age and index dates at a 1:3 ratio. Sex, underlying comorbidities, and monthly income were also included in the analyses. We followed up the participants until 2013 and made comparison of the risk of autoimmune connective tissue disease between participants with and without CO poisoning. Results: The 23,877 participants with CO poisoning had a higher risk for autoimmune connective tissue disease than the 71,631 participants without CO poisoning (adjusted hazard ratio [AHR], 3.5; 95% confidence interval [CI], 3.1-3.9) after adjustment for sex, diabetes, Lyme disease, herpes zoster, infectious mononucleosis, hepatitis, HIV infection, liver disease, renal disease, non-CO poisoning or drug abuse, malignancy, hypertension, hyperlipidemia, coronary artery disease, congestive heart failure, chronic obstructive pulmonary disease, and monthly income. An increased risk was observed even after 4 years of followup (AHR, 3.6; 95% CI, 3.0-4.4). Conclusion: The risk of autoimmune connective tissue disease increased following CO poisoning. Close follow-up of the patients with CO poisoning for the development of connective tissue disease is recommended, and further investigation of the detailed mechanisms is warranted.
關聯:	Clinical Epidemiology, v.12, pp.12
顯示於類別:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
10.2147_CLEP.S266396.pdf		1901Kb	Adobe PDF	360	檢視/開啟
index.html		0Kb	HTML	1905	檢視/開啟

在CNU IR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....