Associations among chronic obstructive pulmonary disease with asthma, pneumonia, and corticosteroid use in the general population

doi:10.1371/journal.pone.0229484

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 職業安全衛生系(含防災所) > 期刊論文 > Item 310902800/34083

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標題:	Associations among chronic obstructive pulmonary disease with asthma, pneumonia, and corticosteroid use in the general population
作者:	Yeh, Jun-Jun Lin, Cheng-Li Kao, Chia-Hung
貢獻者:	Chia Yi Christian Hosp, Ditmanson Med Fdn Chia Nan Univ Pharm & Sci China Med Univ China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med China Med Univ Hosp, Ctr Augmented Intelligence Healthcare China Med Univ, Coll Med, Grad Inst Biomed Sci China Med Univ Hosp, Dept Nucl Med China Med Univ Hosp, PET Ctr Asia Univ, Dept Bioinformat & Med Engni
日期:	2020
上傳時間:	2022-11-18 11:23:12 (UTC+8)
出版者:	Public Library Science
摘要:	Purpose To evaluate the association among chronic obstructive pulmonary disease (COPD) with asthma, steroid use, and pneumonia in the general population. Methods Using Taiwan's National Health Insurance Research Database to identify patients with incident pneumonia, we established a COPD with asthma cohort of 12,538 patients and a COPD cohort of 25,069 patients. In both cohorts, the risk of incident pneumonia was assessed using multivariable Cox proportional hazards models. Results The adjusted hazard ratio (aHR) with 95% confidence interval (CI) for incident pneumonia was 2.38 (2.14, 2.66) in the COPD with asthma cohort, regardless of age, sex, comorbidities, and drug use. COPD cohort without inhaled corticosteroids (ICSs) use served as a reference. The aHR (95% CI) for COPD cohort with ICSs use was 1.34 (0.98, 1.83); that for COPD with asthma cohort without ICSs use was 2.46 (2.20, 2.76); and that for COPD with asthma cohort with ICSs use was 2.32 (1.99, 2.72). COPD cohort without oral steroids (OSs) use served as a reference; the aHR (95% CI) for COPD with asthma cohort without OSs use and with OSs use was 3.25 (2.72, 3.89) and 2.38 (2.07, 2.74), respectively. Conclusions The COPD with asthma cohort had a higher risk of incident pneumonia, regardless of age, sex, comorbidities, and ICSs or OSs use. COPD cohort with ICSs use did not have a notable risk of incident pneumonia. The COPD with asthma cohort had a higher risk of incident pneumonia, even without ICSs/OSs use.
關聯:	Plos One, v.15, n.2, pp.17
顯示於類別:	[職業安全衛生系(含防災所)] 期刊論文

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