Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34076
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    题名: Antiproliferative Effect and Mediation of Apoptosis in Human Hepatoma HepG2 Cells Induced by Djulis Husk and Its Bioactive Compounds
    作者: Tu, Dom-Gene
    Chyau, Charng-Cherng
    Chen, Shih-Ying
    Chu, Heuy-Ling
    Wang, Shu-Chen
    Duh, Pin-Der
    贡献者: ChiaYi Christian Hosp, Ditmanson Med Fdn, Dept Nucl Med
    Natl Chung Cheng Univ, Dept Biomed Sci
    Hungkuang Univ, Biotechnol Res Inst
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
    关键词: antiproliferation
    apoptosis
    djulis husk
    quercetin
    kaempferol
    日期: 2020
    上传时间: 2022-11-18 11:22:56 (UTC+8)
    出版者: Mdpi
    摘要: The antiproliferative effect and mediation of apoptosis in human hepatoma HepG2 cells induced by djulis husk and its bioactive compounds was investigated. The ethanolic extracts of djulis husk (EEDH) at 50, 250, and 500 mu g/mL induced remarkable cytotoxicity on HepG2 cells. By flow cytometry analysis, EEDH slowed down the cell cycle at the Sub-G0 phase after 24 h of incubation. Moreover, all EEDH treatment induced an apoptotic response in HepG2 cells. EEDH-induced apoptosis was associated with the attenuation of mitochondrial transmembrane potentials (Delta psi(m)), an increase in Bax/Bcl-2 ratio, activation of caspase-3, and poly(ADP-ribose)polymerase (PARP) cleavage, as well as an increase in reactive oxygen species (ROS) generation. According to the HPLC-DAD and HPLC-MS/MS analysis, quercetin and kaempferol derivatives and another sixteen compounds were present in EEDH. Quercetin and kaempferol at 25-150 mu M showed antiproliferative action and induced apoptosis on HepG2 cells, which may in part account for the anticancer activity of EEDH. Overall, EEDH may be a potent chemopreventive agent due to apoptosis in HepG2 cells.
    關聯: Foods, v.9, n.10, pp.21
    显示于类别:[Dept. of Health and Nutrition (including master's program)] Periodical Articles
    [Dept. of Food Science & Technology] Periodical Articles

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