Alterations of plasma cytokine biomarkers for identifying age at onset of schizophrenia with neurological soft signs

doi:10.7150/ijms.38891

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Title:	Alterations of plasma cytokine biomarkers for identifying age at onset of schizophrenia with neurological soft signs
Authors:	Liu, Jia-Yun Chen, Han-Yu Lin, Jin-Jia Lu, Ming-Kun Tan, Hung-Pin Jang, Fong-Lin Lin, Sheng-Hsiang
Contributors:	Natl Cheng Kung Univ, Coll Med, Inst Clin Med Changhua Christian Hosp, Ctr Med Genet, Dept Med Res Changhua Christian Hosp, Ctr Med Genet, Dept Genom Med Chimei Med Ctr, Dept Psychiat Jianan Mental Hosp, Dept Hlth Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth Kaohsiung Vet Gen Hosp, Dept Psychiat, Tainan Branch Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Biostat Consulting Ctr
Keywords:	schizophrenia early-onset immune dysregulation neurodevelopment discriminant analysis
Date:	2020
Issue Date:	2022-11-18 11:22:31 (UTC+8)
Publisher:	Ivyspring Int Publ
Abstract:	Several studies have been suggested that immunity plays a part in neurodevelopment and schizophrenia pathogenesis. Early age of onset in schizophrenia is associated with genetic factors which affect neurodevelopment. This study aims to identify immune abnormalities associated with neurodevelopmental impairments in early-onset schizophrenia (EOS) and adult-onset schizophrenia (AOS) patients. We determined the plasma levels of six cytokines (IL-1 beta, IL-4, IL-6, IL-10, IL-12 and TNF-alpha) in schizophrenia patients and healthy controls. Measurements included neurological soft signs (NSS) to distinguish and subgroup those with neurodevelopmental impairments. The study included 210 schizophrenia patients, which were divided into 84 EOS and 126 AOS patients, as well as 122 healthy controls. We observed significant differences in levels of IL-4, IL-6 and IL-10 between EOS and AOS patients. The results demonstrated the area under ROC curve (AUC) of the IL-4 in EOS and healthy controls was 0.81. Moreover, these results indicated that AUC of the IL-4 and the combination of IL-4, IL-6 and IL-12 in EOS with NSS and healthy controls were 0.91 and 0.95. These cytokines are altered in EOS and schizophrenia patients with neurodevelopmental impairments and demonstrated good classification abilities. These findings manifested that both pro- and anti-inflammatory cytokines are contributed to the clinical and pathophysiological features of schizophrenia. Future works are expected to explore potential genetic effectors and predictors as well as therapeutic directions in personalized medicine for early-onset schizophrenia.
Relation:	International Journal of Medical Sciences, v.17, n.2, pp.8
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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