Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34056
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    標題: A green approach for the extraction and characterization of oridonin and ursolic and oleanolic acids from Rabdosia rubescens and its kinetic behavior
    作者: Yang, Yu-Chiao
    Wang, Chia-Sui
    Wei, Ming-Chi
    貢獻者: Kaohsiung Med Univ, Dept & Grad Inst Pharmacol
    Kaohsiung Med Univ Hosp, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Appl Geoinformat
    關鍵字: Rabdosia rubescens
    Oridonin
    Ursolic acid
    Oleanolic acid
    Second-order rate model
    Diffusion model
    Ultrasound-assisted supercritical CO2 extraction
    Thermodynamic parameters
    日期: 2020
    上傳時間: 2022-11-18 11:22:02 (UTC+8)
    出版者: Elsevier Sci Ltd
    摘要: An ultrasound-assisted supercritical carbon dioxide (USC-CO2) procedure was developed for the extraction of ursolic acid, oleanolic acid and oridonin from Rabdosia rubescens, with yields that were 9.84-10.46 and 15.43-21.10% higher than those of the conventional SC-CO2 and heat-reflux extractions, respectively. USC-CO2 uses a shorter extraction time (1.83-2.09 times) and less organic solvent (3.39-173.25 times) to operate at a lower extraction temperature (5-16 degrees C). The dominant component in the extract was oridonin, which may indicate that the kinetic behavior in the extraction system is predominated by that of oridonin. Furthermore, the USC-CO2 and conventional SC-CO2 dynamic extraction kinetics of oridonin from R. rubescens were well described by the second-order rate and Fick's second law models. The extraction rate constant, energy of activation for diffusion, Biot number and thermodynamic parameters were deduced from the data obtained. These results provide valuable insights into the USC-CO2 and conventional SC-CO2 procedures.
    關聯: Food Chemistry, v.319, pp.10
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